Patient outcomes following second surgery for recurrent glioblastoma

Alba A. Brandes, Marco Bartolotti, Alicia Tosoni, Rosalba Poggi, Stefania Bartolini, Alexandro Paccapelo, Antonella Bacci, Claudio Ghimenton, Annalisa Pession, Carlo Bortolotti, Mino Zucchelli, Renato Galzio, Andrea Talacchi, Lorenzo Volpin, Gianluca Marucci, Dario De Biase, Stefano Pizzolitto, Daniela Danieli, Mario Ermani, Enrico Franceschi

Research output: Contribution to journalArticle

Abstract

Background: The most appropriate management of recurrent glioblastoma is still controversial. In particular, the role of surgery at recurrence remains uncertain. Patients & methods: From our Institutional data warehouse we analyzed 270 consecutive patients who received second surgery for recurrent glioblastoma, to assess survival after second surgery, and to evaluate prognostic factors. Results: Complete resection was found in 128 (47.4%) and partial resection in 142 patients (52.6%). Median survival from second surgery was 11.4 months (95% CI: 10.0-12.7). Multivariate analysis showed that age (p = 0.001), MGMT methylation (p = 0.021) and extent of surgery (p <0.001) are associated with better survival. Conclusion: A complete resection should be the goal for second resection and younger age and MGMT methylation status might be considered in the selection of patients.

Original languageEnglish
Pages (from-to)1039-1044
Number of pages6
JournalFuture Oncology
Volume12
Issue number8
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • age
  • glioblastoma
  • MGMT
  • second surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Brandes, A. A., Bartolotti, M., Tosoni, A., Poggi, R., Bartolini, S., Paccapelo, A., Bacci, A., Ghimenton, C., Pession, A., Bortolotti, C., Zucchelli, M., Galzio, R., Talacchi, A., Volpin, L., Marucci, G., De Biase, D., Pizzolitto, S., Danieli, D., Ermani, M., & Franceschi, E. (2016). Patient outcomes following second surgery for recurrent glioblastoma. Future Oncology, 12(8), 1039-1044. https://doi.org/10.2217/fon.16.9