Patient-reported outcomes and low-level residual HIV-RNA in adolescents perinatally infected with HIV-1 after switching to one-pill fixed-dose regimen

Raffaella Rosso, Antonio Di Biagio, Franco Maggiolo, Loredana Nulvesu, Anna Paola Callegaro, Lucia Taramasso, Bianca Bruzzone, Claudio Viscoli

Research output: Contribution to journalArticle

Abstract

The choice of an antiretroviral regimen can often impact on adherence, treatment satisfaction and therefore influence on clinical outcome. These concerns are particularly true in adolescents. In this setting, adherence is usually affected by multifactor events and biopsychosocial factors, which connect and changeover time. We evaluated the effect of a switch to a single-pill fixed-dose regimen on patient-reported outcomes, virologic and immunologic outcomes, and safety in a cohort of adolescents with perinatal HIV-1 infection. In addition, we evaluated the effect on low-level residual HIV-RNA. An open-label, non-randomised study was performed: 12 adolescents with a confirmed viremia

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

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Keywords

  • adherence
  • adolescents
  • HIV
  • HIV-1 residual viremia
  • low-level residual HIV-RNA
  • once-daily antiretroviral regimen

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Social Psychology

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