Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing

Takeshi Yoshida, Domenico L. Grieco, Laurent Brochard, Yuji Fujino

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewThe potential risks of spontaneous effort and their prevention during mechanical ventilation is an important concept for clinicians and patients. The effort-dependent lung injury has been termed 'patient self-inflicted lung injury (P-SILI)' in 2017. As one of the potential strategies to render spontaneous effort less injurious in severe acute respiratory distress syndrome (ARDS), the role of positive end-expiratory pressure (PEEP) is now discussed.Recent findingsExperimental and clinical data indicate that vigorous spontaneous effort may worsen lung injury, whereas, at the same time, the intensity of spontaneous effort seems difficult to control when lung injury is severe. Experimental studies found that higher PEEP strategy can be effective to reduce lung injury from spontaneous effort while maintaining some muscle activity. The recent clinical trial to reevaluate systemic early neuromuscular blockade in moderate-severe ARDS (i.e., reevaluation of systemic early neuromuscular blockade (ROSE) trial) support that a higher PEEP strategy can facilitate 'safe' spontaneous breathing under the light sedation targets (i.e., no increase in barotrauma nor 90 days mortality versus early muscle paralysis).SummaryTo prevent P-SILI in ARDS, it seems feasible to facilitate 'safe' spontaneous breathing in patients using a higher PEEP strategy in severe ARDS.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalCurrent Opinion in Critical Care
Issue number1
Publication statusPublished - Feb 1 2020
Externally publishedYes


  • acute respiratory distress syndrome
  • mechanical ventilation
  • positive end-expiratory pressure
  • spontaneous breathing

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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