Patients recovering from COVID-19 pneumonia at a sub-acute admissions unit exhibit profound muscular weakness

studies describe a wide variety of clinical presentations for co-Vid-19 infection, ranging from absence of symptoms to pneumo-nia with acute respiratory failure (arf). arf is associated with prolonged functional impairment in many individuals, and recov-ery from this critical illness is fraught with challenges. Moreover, there is increasing evidence that coVid-19 directly and indirectly
produces a complex pathology, characterized by polysystemic
involvement ranging from damage to the cardio-respiratory sys-tem up to complications affecting the central and peripheral ner-vous system.1 previous post-mortem examinations documented
immune-mediated focal myofibrillar necrosis and muscular at-rophy in severe acute respiratory syndrome (sars) patients and
it has been hypothesized that also SARS-CoV-2 can cause mus-cular damage in the spectrum of myophatic changes induced by the pathogen.