Patients with acute myocardial infarction in Northern Italy are often infected by Helicobacter pylori

R. Pellicano, P. P. Parravicini, R. Bigi, M. T. La Rovere, G. Baduini, N. Gandolfo, M. Casaccia, F. Reforzo, L. Santoriello, E. Aruta, G. Marenco, V. Arena, F. Bazzoli, M. Rizzetto, A. Ponzetto

Research output: Contribution to journalArticle

Abstract

Background. The classical risk factors for acute myocardial infarction (AMI) fail to explain all the epidemiological variations of the disease. Among the new risk factors recently reported, several infectious agents appear to increase the risk of AMI. In particular, acute and chronic respiratory diseases due to Chlamydia pneumoniae, and Helicobacter pylori (H. pylori) infection seem to be strongly involved. The aim of this work is to determine the prevalence of H. pylori infection in a group of male patients with AMI, in a case-control study, where a group of blood donors matched for sex and age served as control. We searched for the classical risk factors in all patients. Methods. We studied 212 consecutive male patients, aged 40-65 years, admitted for AMI at the Coronary Care Units at Hospitals in three towns of Northern Italy. H. pylori infection was assessed by the highly specific and sensitive 13C-urea breath test and by presence of antibodies (IgG) against H. pylori in circulation. Volunteer blood donors attending our Hospital Blood Bank served as controls. Among the patients we investigated the presence of hypertension, cholesterol and glucose levels in serum, fibrinogen in plasma and the smoking habit. Results. H. pylori infection was present in 187/212 (88%) of the patients and in 183/310 (59%) of the control population (p

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalPanminerva Medica
Volume41
Publication statusPublished - Dec 1999

Keywords

  • Coronary disease
  • Helicobacter infection
  • Helicobacter pylori
  • Myocardial infarction
  • Myocardial ischemia

ASJC Scopus subject areas

  • Medicine(all)

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    Pellicano, R., Parravicini, P. P., Bigi, R., La Rovere, M. T., Baduini, G., Gandolfo, N., Casaccia, M., Reforzo, F., Santoriello, L., Aruta, E., Marenco, G., Arena, V., Bazzoli, F., Rizzetto, M., & Ponzetto, A. (1999). Patients with acute myocardial infarction in Northern Italy are often infected by Helicobacter pylori. Panminerva Medica, 41, 279-282.