Patients with allergic rhinitis show an allergen-specific interferon-gamma defect

D. Fenoglio, A. Ferrera, F. Ferrera, M. P. Sormani, M. Di Gioacchino, Giorgio Ciprandi

Research output: Contribution to journalArticle

Abstract

Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Consequently, allergic patients have a defect in IFN-γ production. So far, however, all the experimental studies have investigated only the IFN-γ production induced by the causal allergen. The aim of this study is to investigate whether there is a difference in the in vitro IFN-γ production, using different allergens as stimuli, in patients presenting with rhinitis due to pollen allergy. Forty-one AR patients with pollen allergy were enrolled. IFN-γ-specific producing cells were stimulated with PHA, causal pollen, and House Dust Mite (HDM). IFN-γ production was assessed by cytokine ELISPOT. IFN-γ production of peripheral blood mononuclear cells (PBMC) stimulated by specific pollen was significantly lower than IFN-γ production of PBMC stimulated by HDM (p

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalEuropean Journal of Inflammation
Volume6
Issue number2
Publication statusPublished - May 2008

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Keywords

  • Allergic rhinitis
  • ELISPOT
  • IFN-γ production
  • Mites
  • Pollens
  • Th1 cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Fenoglio, D., Ferrera, A., Ferrera, F., Sormani, M. P., Di Gioacchino, M., & Ciprandi, G. (2008). Patients with allergic rhinitis show an allergen-specific interferon-gamma defect. European Journal of Inflammation, 6(2), 87-91.