Patients with erosive lichen planus may have antibodies directed to a nuclear antigen of epithelial cells: A study on the antigen nature

Aurora Parodi, P. P. Cardo

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Two patients with erosive lichen planus and latent HBV infection who had circulating antibodies directed to nuclei of epithelial cells are described. The nature of such antigen has been investigated by indirect immunofluorescence, double immunodiffusion, counterimmunoelectrophoresis, enzyme-linked immunosorbent assay, enzyme treatments, and immunoblotting. The antigen cannot be identified as RNP, histone, soluble nuclear protein, nDNA, or ssDNA. It may be a DNA protein complex and preliminary immunoblotting data support the thesis that it may be a multimolecular complex.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalJournal of Investigative Dermatology
Volume94
Issue number5
Publication statusPublished - May 1990

Fingerprint

Lichen Planus
Nuclear Antigens
Immunoblotting
Epithelial Cells
Counterimmunoelectrophoresis
Antigens
Immunosorbents
Antibodies
Immunodiffusion
Enzymes
Indirect Fluorescent Antibody Technique
Nuclear Proteins
Histones
Assays
Enzyme-Linked Immunosorbent Assay
DNA
Infection
Proteins
Lichens
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

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abstract = "Two patients with erosive lichen planus and latent HBV infection who had circulating antibodies directed to nuclei of epithelial cells are described. The nature of such antigen has been investigated by indirect immunofluorescence, double immunodiffusion, counterimmunoelectrophoresis, enzyme-linked immunosorbent assay, enzyme treatments, and immunoblotting. The antigen cannot be identified as RNP, histone, soluble nuclear protein, nDNA, or ssDNA. It may be a DNA protein complex and preliminary immunoblotting data support the thesis that it may be a multimolecular complex.",
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