Patients with erosive lichen planus may have antibodies directed to a nuclear antigen of epithelial cells: A study on the antigen nature

Aurora Parodi, P. P. Cardo

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Two patients with erosive lichen planus and latent HBV infection who had circulating antibodies directed to nuclei of epithelial cells are described. The nature of such antigen has been investigated by indirect immunofluorescence, double immunodiffusion, counterimmunoelectrophoresis, enzyme-linked immunosorbent assay, enzyme treatments, and immunoblotting. The antigen cannot be identified as RNP, histone, soluble nuclear protein, nDNA, or ssDNA. It may be a DNA protein complex and preliminary immunoblotting data support the thesis that it may be a multimolecular complex.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalJournal of Investigative Dermatology
Issue number5
Publication statusPublished - May 1990


ASJC Scopus subject areas

  • Dermatology

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