Patients with microvascular obstruction after primary percutaneous coronary intervention show a gp91phox (NOX2) mediated persistent oxidative stress after reperfusion

Giampaolo Niccoli, Andrea Celestini, Camilla Calvieri, Nicola Cosentino, Elena Falcioni, Roberto Carnevale, Cristina Nocella, Francesco Fracassi, Marco Roberto, Roberta P. Antonazzo, Pasquale Pignatelli, Filippo Crea, Francesco Violi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Persistent oxidative stress may play a key role in microvascular obstruction (MVO). We aimed at assessing the role of platelet gp91phox (NOX2), the catalytic subunit of NADPH oxidase in MVO. Methods: We enrolled 40 patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention within 12 h from symptoms onset, either with angiographic MVO (n=20) or good angiographic myocardial reperfusion (MR) (n=20). Angiographic MVO was defined as a final thrombolysis in myocardial infarction (TIMI) flow ≤2 or TIMI flow of 3 with myocardial blush grade 2α showed a trend to increase from baseline to pre-discharge in angiographic MVO patients (295 (183.50-389.25) pmol/l vs 322 (206-370) pmol/l, p=0.06), but not in patients with MR (p=0.56), with a trend for interaction between baseline and pre-discharge levels among the two groups (p=0.09). Conclusion: Patients with MVO, but not those with myocardial reperfusion, have a sustained increase of NOX2 and 8-iso-PGF. Therapies targeting NOX2 or high dosage antioxidants should be tested for MVO prevention and treatment.

Original languageEnglish
Pages (from-to)379-388
Number of pages10
JournalEuropean Heart Journal: Acute Cardiovascular Care
Volume2
Issue number4
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Critical Care and Intensive Care Medicine

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