Patients with migraine with aura have increased flow mediated dilation

Fabrizio Vernieri, Leo Moro, Claudia Altamura, Paola Palazzo, Raffaele Antonelli Incalzi, Paolo M. Rossini, Claudio Pedone

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Endothelium-derived nitric oxide (NO) mediates the arterial dilation following a flow increase (i.e. flow-mediated dilation, FMD), easily assessed in the brachial artery. NO is also involved in cerebral hemodynamics and it is supposed to trigger vascular changes occurring during migraine. This study aimed at investigating whether migraine patients present an altered response to NO also in the peripheral artery system.Methods: We enrolled 21 migraineurs (10 with aura [MwA], 11 without aura [MwoA]), and 13 controls. FMD was evaluated with ultrasound in all subjects by measuring the percentage increase of the brachial artery diameter induced by hyperaemia reactive to sustained cuff inflation around the arm above systolic pressure. FMD values were then normalized for shear stress.Results: Normalized FMD values were higher in patients with MwA (28.5 10-2%.s) than in controls (9.0 10-2%.s) and patients with MwoA (13.7 10-2%.s) (p <0.001). FMD was over the median value (19%) in 23.1% of controls, in 45.5% of the MwoA patients, and in 90% of the MwA patients.Conclusions: Migraineurs with aura present an excessive arterial response to hyperaemia, likely as an effect of an increased sensitivity to endothelium-derived nitric oxide. This phenomenon observed peripherally might reflect similar characteristics in the cerebral circulation.

Original languageEnglish
Article number18
JournalBMC Neurology
Volume10
DOIs
Publication statusPublished - Mar 10 2010

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Migraine with Aura
Dilatation
Epilepsy
Nitric Oxide
Brachial Artery
Hyperemia
Migraine Disorders
Cerebrovascular Circulation
Economic Inflation
Blood Vessels
Arteries
Hemodynamics
Blood Pressure

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Vernieri, F., Moro, L., Altamura, C., Palazzo, P., Antonelli Incalzi, R., Rossini, P. M., & Pedone, C. (2010). Patients with migraine with aura have increased flow mediated dilation. BMC Neurology, 10, [18]. https://doi.org/10.1186/1471-2377-10-18

Patients with migraine with aura have increased flow mediated dilation. / Vernieri, Fabrizio; Moro, Leo; Altamura, Claudia; Palazzo, Paola; Antonelli Incalzi, Raffaele; Rossini, Paolo M.; Pedone, Claudio.

In: BMC Neurology, Vol. 10, 18, 10.03.2010.

Research output: Contribution to journalArticle

Vernieri, F, Moro, L, Altamura, C, Palazzo, P, Antonelli Incalzi, R, Rossini, PM & Pedone, C 2010, 'Patients with migraine with aura have increased flow mediated dilation', BMC Neurology, vol. 10, 18. https://doi.org/10.1186/1471-2377-10-18
Vernieri F, Moro L, Altamura C, Palazzo P, Antonelli Incalzi R, Rossini PM et al. Patients with migraine with aura have increased flow mediated dilation. BMC Neurology. 2010 Mar 10;10. 18. https://doi.org/10.1186/1471-2377-10-18
Vernieri, Fabrizio ; Moro, Leo ; Altamura, Claudia ; Palazzo, Paola ; Antonelli Incalzi, Raffaele ; Rossini, Paolo M. ; Pedone, Claudio. / Patients with migraine with aura have increased flow mediated dilation. In: BMC Neurology. 2010 ; Vol. 10.
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