Abstract
Objective: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. Methods: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies. Results: We demonstrated that the protein bands recognized by the serum of the rabbit immunized with an epitope of chronic ulcerative stomatitis protein co-migrated by SDS-PAGE with the protein bands recognized by the serum of a patient affected by oral erosive lichen planus and by the serum of a patient with cutaneous lichen planus, both containing antibodies directed against a 70-kDa antigen. Conclusions: Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planus.
| Original language | English |
|---|---|
| Pages (from-to) | 120-124 |
| Number of pages | 5 |
| Journal | Acta Dermatovenerologica Alpina, Panonica et Adriatica |
| Volume | 17 |
| Issue number | 3 |
| Publication status | Published - Sep 2008 |
Fingerprint
Keywords
- Antinuclear antibodies
- Chronic ulcerative stomatitis
- Erosive lichen planus
ASJC Scopus subject areas
- Dermatology
- Infectious Diseases
Cite this
Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa. / Cozzani, Emanuele; Cacciapuoti, Marco; Di Marco, Eddi; Zerega, Barbara; Cancedda, Fiorella Descalzi; Parodi, Aurora.
In: Acta Dermatovenerologica Alpina, Panonica et Adriatica, Vol. 17, No. 3, 09.2008, p. 120-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa
AU - Cozzani, Emanuele
AU - Cacciapuoti, Marco
AU - Di Marco, Eddi
AU - Zerega, Barbara
AU - Cancedda, Fiorella Descalzi
AU - Parodi, Aurora
PY - 2008/9
Y1 - 2008/9
N2 - Objective: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. Methods: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies. Results: We demonstrated that the protein bands recognized by the serum of the rabbit immunized with an epitope of chronic ulcerative stomatitis protein co-migrated by SDS-PAGE with the protein bands recognized by the serum of a patient affected by oral erosive lichen planus and by the serum of a patient with cutaneous lichen planus, both containing antibodies directed against a 70-kDa antigen. Conclusions: Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planus.
AB - Objective: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. Methods: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies. Results: We demonstrated that the protein bands recognized by the serum of the rabbit immunized with an epitope of chronic ulcerative stomatitis protein co-migrated by SDS-PAGE with the protein bands recognized by the serum of a patient affected by oral erosive lichen planus and by the serum of a patient with cutaneous lichen planus, both containing antibodies directed against a 70-kDa antigen. Conclusions: Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planus.
KW - Antinuclear antibodies
KW - Chronic ulcerative stomatitis
KW - Erosive lichen planus
UR - http://www.scopus.com/inward/record.url?scp=55049134078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55049134078&partnerID=8YFLogxK
M3 - Article
C2 - 18853074
AN - SCOPUS:55049134078
VL - 17
SP - 120
EP - 124
JO - Acta Dermatovenerologica Alpina, Panonica et Adriatica
JF - Acta Dermatovenerologica Alpina, Panonica et Adriatica
SN - 1318-4458
IS - 3
ER -