Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: A voxel-based morphometry study of treatment resistance in Schizophrenia

Mario Quarantelli, Olga Palladino, Anna Prinster, Vittorio Schiavone, Barbara Carotenuto, Arturo Brunetti, Angela Marsili, Margherita Casiello, Giovanni Muscettola, Marco Salvatore, Andrea De Bartolomeis

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Abstract

Approximately 30% of schizophrenia patients do not respond adequately to the therapy. Previous MRI studies have suggested that drug treatment resistance is associated with brain morphological abnormalities, although region-of-interest analysis of MR studies from nonresponder and responder patients failed to demonstrate a statistically significant difference between these two schizophrenia subgroups. We have used a voxel-based analysis of segmented MR studies to assess structural cerebral differences in 20 nonresponder and 15 responder patients and 16 age-matched normal volunteers. Differences between the three groups emerged bilaterally mainly at the level of the superior and middle frontal gyri, primarily due to reduced grey matter volumes in nonresponders, as compared to both normal volunteers and responder patients. Post hoc direct comparison between the two schizophrenia subgroups demonstrated significantly reduced grey matter volumes in middle frontal gyrus bilaterally, in the dorsolateral aspects of left superior frontal gyrus extending into postcentral gyrus and in the right medial temporal cortex. Our results extend and integrate previous findings suggesting amore severe atrophy in nonresponder schizophrenia patients, compared to responder patients, mainly at the level of the superior and middle frontal gyri. Longitudinal studies in drug-näive patients are needed to assess the role of these associations.

Original languageEnglish
Article number325052
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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    Quarantelli, M., Palladino, O., Prinster, A., Schiavone, V., Carotenuto, B., Brunetti, A., Marsili, A., Casiello, M., Muscettola, G., Salvatore, M., & De Bartolomeis, A. (2014). Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: A voxel-based morphometry study of treatment resistance in Schizophrenia. BioMed Research International, 2014, [325052]. https://doi.org/10.1155/2014/325052