Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Stefania Zanetti; Alessandra Bua; Giovanni Delogu; Cinzia Pusceddu; Maristella Mura; Franca Saba; Piero Pirina; Carlo Garzelli; Cono Vertuccio; Leonardo A. Sechi; Giovanni Fadda

doi:10.1128/CDLI.12.9.1135-1138.2005

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Stefania Zanetti, Alessandra Bua, Giovanni Delogu, Cinzia Pusceddu, Maristella Mura, Franca Saba, Piero Pirina, Carlo Garzelli, Cono Vertuccio, Leonardo A. Sechi, Giovanni Fadda

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

Original language	English
Pages (from-to)	1135-1138
Number of pages	4
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1128/CDLI.12.9.1135-1138.2005
Publication status	Published - Sep 2005

ASJC Scopus subject areas

Microbiology (medical)
Immunology and Allergy
Clinical Biochemistry
Immunology

Access to Document

10.1128/CDLI.12.9.1135-1138.2005

Cite this

Zanetti, S., Bua, A., Delogu, G., Pusceddu, C., Mura, M., Saba, F., Pirina, P., Garzelli, C., Vertuccio, C., Sechi, L. A., & Fadda, G. (2005). Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. Clinical and Diagnostic Laboratory Immunology, 12(9), 1135-1138. https://doi.org/10.1128/CDLI.12.9.1135-1138.2005

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. / Zanetti, Stefania; Bua, Alessandra; Delogu, Giovanni; Pusceddu, Cinzia; Mura, Maristella; Saba, Franca; Pirina, Piero; Garzelli, Carlo; Vertuccio, Cono; Sechi, Leonardo A.; Fadda, Giovanni.

In: Clinical and Diagnostic Laboratory Immunology, Vol. 12, No. 9, 09.2005, p. 1135-1138.

Research output: Contribution to journal › Article › peer-review

Zanetti, S, Bua, A, Delogu, G, Pusceddu, C, Mura, M, Saba, F, Pirina, P, Garzelli, C, Vertuccio, C, Sechi, LA & Fadda, G 2005, 'Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin', Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 9, pp. 1135-1138. https://doi.org/10.1128/CDLI.12.9.1135-1138.2005

Zanetti, Stefania ; Bua, Alessandra ; Delogu, Giovanni ; Pusceddu, Cinzia ; Mura, Maristella ; Saba, Franca ; Pirina, Piero ; Garzelli, Carlo ; Vertuccio, Cono ; Sechi, Leonardo A. ; Fadda, Giovanni. / Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. In: Clinical and Diagnostic Laboratory Immunology. 2005 ; Vol. 12, No. 9. pp. 1135-1138.

@article{4d540f45898044f2a78bd8d86d2e1013,

title = "Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin",

abstract = "Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.",

author = "Stefania Zanetti and Alessandra Bua and Giovanni Delogu and Cinzia Pusceddu and Maristella Mura and Franca Saba and Piero Pirina and Carlo Garzelli and Cono Vertuccio and Sechi, {Leonardo A.} and Giovanni Fadda",

year = "2005",

month = sep,

doi = "10.1128/CDLI.12.9.1135-1138.2005",

language = "English",

volume = "12",

pages = "1135--1138",

journal = "Clinical and Diagnostic Laboratory Immunology",

issn = "1071-412X",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

AU - Zanetti, Stefania

AU - Bua, Alessandra

AU - Delogu, Giovanni

AU - Pusceddu, Cinzia

AU - Mura, Maristella

AU - Saba, Franca

AU - Pirina, Piero

AU - Garzelli, Carlo

AU - Vertuccio, Cono

AU - Sechi, Leonardo A.

AU - Fadda, Giovanni

PY - 2005/9

Y1 - 2005/9

N2 - Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

AB - Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

UR - http://www.scopus.com/inward/record.url?scp=24944475556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944475556&partnerID=8YFLogxK

U2 - 10.1128/CDLI.12.9.1135-1138.2005

DO - 10.1128/CDLI.12.9.1135-1138.2005

M3 - Article

C2 - 16148186

AN - SCOPUS:24944475556

VL - 12

SP - 1135

EP - 1138

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

SN - 1071-412X

IS - 9

ER -

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this