Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Stefania Zanetti; Alessandra Bua; Giovanni Delogu; Cinzia Pusceddu; Maristella Mura; Franca Saba; Piero Pirina; Carlo Garzelli; Cono Vertuccio; Leonardo A. Sechi; Giovanni Fadda

doi:10.1128/CDLI.12.9.1135-1138.2005

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Stefania Zanetti, Alessandra Bua, Giovanni Delogu, Cinzia Pusceddu, Maristella Mura, Franca Saba, Piero Pirina, Carlo Garzelli, Cono Vertuccio, Leonardo A. Sechi, Giovanni Fadda

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

Original language	English
Pages (from-to)	1135-1138
Number of pages	4
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1128/CDLI.12.9.1135-1138.2005
Publication status	Published - Sep 2005

ASJC Scopus subject areas

Microbiology (medical)
Immunology and Allergy
Clinical Biochemistry
Immunology

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Zanetti, S., Bua, A., Delogu, G., Pusceddu, C., Mura, M., Saba, F., Pirina, P., Garzelli, C., Vertuccio, C., Sechi, L. A., & Fadda, G. (2005). Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. Clinical and Diagnostic Laboratory Immunology, 12(9), 1135-1138. https://doi.org/10.1128/CDLI.12.9.1135-1138.2005

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. / Zanetti, Stefania; Bua, Alessandra; Delogu, Giovanni; Pusceddu, Cinzia; Mura, Maristella; Saba, Franca; Pirina, Piero; Garzelli, Carlo; Vertuccio, Cono; Sechi, Leonardo A.; Fadda, Giovanni.

In: Clinical and Diagnostic Laboratory Immunology, Vol. 12, No. 9, 09.2005, p. 1135-1138.

Research output: Contribution to journal › Article

Zanetti, S, Bua, A, Delogu, G, Pusceddu, C, Mura, M, Saba, F, Pirina, P, Garzelli, C, Vertuccio, C, Sechi, LA & Fadda, G 2005, 'Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin', Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 9, pp. 1135-1138. https://doi.org/10.1128/CDLI.12.9.1135-1138.2005

Zanetti, Stefania ; Bua, Alessandra ; Delogu, Giovanni ; Pusceddu, Cinzia ; Mura, Maristella ; Saba, Franca ; Pirina, Piero ; Garzelli, Carlo ; Vertuccio, Cono ; Sechi, Leonardo A. ; Fadda, Giovanni. / Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. In: Clinical and Diagnostic Laboratory Immunology. 2005 ; Vol. 12, No. 9. pp. 1135-1138.

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