Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Stefania Zanetti, Alessandra Bua, Giovanni Delogu, Cinzia Pusceddu, Maristella Mura, Franca Saba, Piero Pirina, Carlo Garzelli, Cono Vertuccio, Leonardo A. Sechi, Giovanni Fadda

Research output: Contribution to journalArticlepeer-review

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

Original languageEnglish
Pages (from-to)1135-1138
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Clinical Biochemistry
  • Immunology

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