Patients with Type 3 Severe von Willebrand Disease Are Not Protected Against Atherosclerosis: Results from a Multicenter Study in 47 Patients

A. Šrámek, P. Bucciarelli, A. B. Federici, P. M. Mannucci, V. De Rosa, G. Castaman, M. Morfini, M. G. Mazzucconi, A. Rocino, M. Schiavoni, F. A. Scaraggi, J. H C Reiber, F. R. Rosendaal

Research output: Contribution to journalArticle

Abstract

Background-The results of a number of studies in pigs and mice suggest that absence of von Willebrand factor (vWF) protects against the development of atherosclerosis. We studied whether patients with a complete deficiency of vWF (type 3 von Willebrand disease [vWD]) develop fewer atherosclerotic vessel wall changes than healthy controls. Methods and Results-This study included 47 individuals with type 3 vWD and 84 healthy controls. Early atherosclerotic changes were assessed by measuring the thickness of the intima-media in the carotid and femoral arteries by B-mode ultrasonography. Advanced atherosclerotic changes were quantified by summing the maximal thickness of atherosclerotic plaques in the carotid and femoral arteries and were expressed as a plaque score. Established risk factors were determined to adjust for possible differences between the groups. We found no substantial difference in intima-media thickness between vWD patients and controls (adjusted difference for carotid artery 0.007 mm, 95% CI -0.022 to 0.036 mm; femoral artery 0.069 mm, 95% CI -0.056 to 0.19 mm). Similar proportions of patients and controls had atherosclerotic plaques (19% and 17%, respectively). No difference was found in the plaque score between groups (adjusted difference -0.22 mm, 95% CI -0.69 to 0.26). Among vWD patients, we found no effect of treatment with vWF concentrates on intima-media thickness or plaque score. Conclusions-The results of this study indicate that vWF does not play a substantial role in human atherogenesis.

Original languageEnglish
Pages (from-to)740-744
Number of pages5
JournalCirculation
Volume109
Issue number6
DOIs
Publication statusPublished - Feb 17 2004

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Carotid arteries
  • Coagulation
  • Von Willebrand factor

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Šrámek, A., Bucciarelli, P., Federici, A. B., Mannucci, P. M., De Rosa, V., Castaman, G., Morfini, M., Mazzucconi, M. G., Rocino, A., Schiavoni, M., Scaraggi, F. A., Reiber, J. H. C., & Rosendaal, F. R. (2004). Patients with Type 3 Severe von Willebrand Disease Are Not Protected Against Atherosclerosis: Results from a Multicenter Study in 47 Patients. Circulation, 109(6), 740-744. https://doi.org/10.1161/01.CIR.0000112567.53841.10