Pattern electroretinogram detects localized glaucoma defects

Tommaso Salgarello, Andrea Giudiceandrea, Luigi Calandriello, Dario Marangoni, Alberto Colotto, Aldo Caporossi, Benedetto Falsini

Research output: Contribution to journalArticle

Abstract

Purpose: We evaluated the clinical ability of pattern electroretinogram (PERG) to detect functional losses in the affected hemifield of open-angle glaucoma patients with localized perimetric defects. Methods: Hemifield (horizontally-defined) steady-state PERGs (h-PERGs) were recorded in response to 1.7 c/deg alternating gratings from 32 eyes of 29 glaucomatous patients with a perimetric, focal one-hemifield defect, 10 eyes of 10 glaucomatous patients with a diffuse perimetric defect, and 18 eyes of 18 age-matched normal subjects. Standard automated perimetry (SAP) and spectral-domain optical coherence tomography (SD-OCT) for retinal nerve fiber layer (RNFL) thickness also were performed. h-PERG amplitudes and ratios, calculated corresponding hemifield perimetric deviations, as well as hemiretina RNFL thicknesses were analyzed. Results: h-PERG amplitudes, perimetric deviations, and RNFL thicknesses showed losses (P < 0.001) when comparing affected with unaffected hemifields of localized glaucomatous eyes. No differences were found in h-PERG amplitudes between hemifields of normal or diffuse glaucomatous eyes. h-PERG amplitude ratios (affected/ unaffected hemifield) in localized glaucoma were lower (P < 0.001) than the ratios from normal or diffuse glaucomatous eyes. The areas under the receiver operating characteristic curves for h-PERG amplitude ratios, comparing localized-defect glaucomatous eyes with normal or diffuse glaucomatous eyes, were 0.93 and 0.91, respectively. Conclusions: h-PERG assessment showed good diagnostic accuracy to confirm localized glaucomatous defects detected perimetrically. This test may be particularly useful in cognitively impaired patients or young/nonverbal patients unable to provide reliable visual fields. Translational Relevance: h-PERG provides a sensitive objective measure to confirm.

Original languageEnglish
Article number6
JournalTranslational Vision Science and Technology
Volume7
Issue number5
DOIs
Publication statusPublished - Sep 1 2018

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Glaucoma
Defects
Nerve Fibers
Fibers
Optical tomography
Visual Field Tests
Open Angle Glaucoma
Optical Coherence Tomography
Visual Fields
ROC Curve

Keywords

  • Electroretinogram
  • Glaucoma
  • Hemifield
  • Hemiretina
  • Localized defect

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

Cite this

Pattern electroretinogram detects localized glaucoma defects. / Salgarello, Tommaso; Giudiceandrea, Andrea; Calandriello, Luigi; Marangoni, Dario; Colotto, Alberto; Caporossi, Aldo; Falsini, Benedetto.

In: Translational Vision Science and Technology, Vol. 7, No. 5, 6, 01.09.2018.

Research output: Contribution to journalArticle

Salgarello T, Giudiceandrea A, Calandriello L, Marangoni D, Colotto A, Caporossi A et al. Pattern electroretinogram detects localized glaucoma defects. Translational Vision Science and Technology. 2018 Sep 1;7(5). 6. https://doi.org/10.1167/tvst.7.5.6
Salgarello, Tommaso ; Giudiceandrea, Andrea ; Calandriello, Luigi ; Marangoni, Dario ; Colotto, Alberto ; Caporossi, Aldo ; Falsini, Benedetto. / Pattern electroretinogram detects localized glaucoma defects. In: Translational Vision Science and Technology. 2018 ; Vol. 7, No. 5.
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