Abstract
To investigate pattern electroretinogram changes in treated ocular hypertension, we evaluated pattern electroretinogram recordings of 48 hypertensive eyes following an 8-month timolol maleate therapy. During treatment, 27 of 48 eyes had normalized intraocular pressures (15–18 mm Hg), while 21 retained elevated values (21–25 mm Hg). Twenty-eight eyes with untreated hypertension (22–25 mm Hg) lasting at least 8 months, as well as 32 untreated, normotensive eyes served as controls. When compared to untreated normotensive controls, timolol-treated eyes with either elevated or normalized intraocular pressures showed reductions in the mean electroretinographic amplitudes. However, these amplitude reductions were substantially greater in treated eyes with elevated pressures as compared to those with normalized ones. Untreated hypertensive controls showed pattern electroretinogram reductions, with respect to normal values, that were comparable to those of treated hypertensive eyes, but larger than those of treated normotensive ones. These results indicate that, in treated ocular hypertension, pattern electroretinogram losses tend to be associated with moderately increased intraocular pressures in the range of 21–25 mm Hg. Electro retinographic abnormalities may be, at least in part, prevented only by lowering intraocular pressure into a normal range.
| Original language | English |
|---|---|
| Pages (from-to) | 168-177 |
| Number of pages | 10 |
| Journal | Ophthalmic Research |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Intraocular pressure
- Ocular hypertension
- Pattern electroretinogram
- Spatial frequency
- Timolol maleate
ASJC Scopus subject areas
- Ophthalmology
- Cellular and Molecular Neuroscience
- Sensory Systems
Cite this
Pattern electroretinogram in treated ocular hypertension : A cross-sectional study after timolol maleate therapy. / Colotto, A.; Salgarello, T.; Giudiceandrea, A.; De Luca, L. A.; Coppè, A.; Buzzonetti, L.; Falsini, B.
In: Ophthalmic Research, Vol. 27, No. 3, 1995, p. 168-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pattern electroretinogram in treated ocular hypertension
T2 - A cross-sectional study after timolol maleate therapy
AU - Colotto, A.
AU - Salgarello, T.
AU - Giudiceandrea, A.
AU - De Luca, L. A.
AU - Coppè, A.
AU - Buzzonetti, L.
AU - Falsini, B.
PY - 1995
Y1 - 1995
N2 - To investigate pattern electroretinogram changes in treated ocular hypertension, we evaluated pattern electroretinogram recordings of 48 hypertensive eyes following an 8-month timolol maleate therapy. During treatment, 27 of 48 eyes had normalized intraocular pressures (15–18 mm Hg), while 21 retained elevated values (21–25 mm Hg). Twenty-eight eyes with untreated hypertension (22–25 mm Hg) lasting at least 8 months, as well as 32 untreated, normotensive eyes served as controls. When compared to untreated normotensive controls, timolol-treated eyes with either elevated or normalized intraocular pressures showed reductions in the mean electroretinographic amplitudes. However, these amplitude reductions were substantially greater in treated eyes with elevated pressures as compared to those with normalized ones. Untreated hypertensive controls showed pattern electroretinogram reductions, with respect to normal values, that were comparable to those of treated hypertensive eyes, but larger than those of treated normotensive ones. These results indicate that, in treated ocular hypertension, pattern electroretinogram losses tend to be associated with moderately increased intraocular pressures in the range of 21–25 mm Hg. Electro retinographic abnormalities may be, at least in part, prevented only by lowering intraocular pressure into a normal range.
AB - To investigate pattern electroretinogram changes in treated ocular hypertension, we evaluated pattern electroretinogram recordings of 48 hypertensive eyes following an 8-month timolol maleate therapy. During treatment, 27 of 48 eyes had normalized intraocular pressures (15–18 mm Hg), while 21 retained elevated values (21–25 mm Hg). Twenty-eight eyes with untreated hypertension (22–25 mm Hg) lasting at least 8 months, as well as 32 untreated, normotensive eyes served as controls. When compared to untreated normotensive controls, timolol-treated eyes with either elevated or normalized intraocular pressures showed reductions in the mean electroretinographic amplitudes. However, these amplitude reductions were substantially greater in treated eyes with elevated pressures as compared to those with normalized ones. Untreated hypertensive controls showed pattern electroretinogram reductions, with respect to normal values, that were comparable to those of treated hypertensive eyes, but larger than those of treated normotensive ones. These results indicate that, in treated ocular hypertension, pattern electroretinogram losses tend to be associated with moderately increased intraocular pressures in the range of 21–25 mm Hg. Electro retinographic abnormalities may be, at least in part, prevented only by lowering intraocular pressure into a normal range.
KW - Intraocular pressure
KW - Ocular hypertension
KW - Pattern electroretinogram
KW - Spatial frequency
KW - Timolol maleate
UR - http://www.scopus.com/inward/record.url?scp=0029128194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029128194&partnerID=8YFLogxK
U2 - 10.1159/000267663
DO - 10.1159/000267663
M3 - Article
C2 - 8538995
AN - SCOPUS:0029128194
VL - 27
SP - 168
EP - 177
JO - Ophthalmic Research
JF - Ophthalmic Research
SN - 0030-3747
IS - 3
ER -