Pattern electroretinogram in treated ocular hypertension: A cross-sectional study after timolol maleate therapy

A. Colotto, T. Salgarello, A. Giudiceandrea, L. A. De Luca, A. Coppè, L. Buzzonetti, B. Falsini

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To investigate pattern electroretinogram changes in treated ocular hypertension, we evaluated pattern electroretinogram recordings of 48 hypertensive eyes following an 8-month timolol maleate therapy. During treatment, 27 of 48 eyes had normalized intraocular pressures (15–18 mm Hg), while 21 retained elevated values (21–25 mm Hg). Twenty-eight eyes with untreated hypertension (22–25 mm Hg) lasting at least 8 months, as well as 32 untreated, normotensive eyes served as controls. When compared to untreated normotensive controls, timolol-treated eyes with either elevated or normalized intraocular pressures showed reductions in the mean electroretinographic amplitudes. However, these amplitude reductions were substantially greater in treated eyes with elevated pressures as compared to those with normalized ones. Untreated hypertensive controls showed pattern electroretinogram reductions, with respect to normal values, that were comparable to those of treated hypertensive eyes, but larger than those of treated normotensive ones. These results indicate that, in treated ocular hypertension, pattern electroretinogram losses tend to be associated with moderately increased intraocular pressures in the range of 21–25 mm Hg. Electro retinographic abnormalities may be, at least in part, prevented only by lowering intraocular pressure into a normal range.

Original languageEnglish
Pages (from-to)168-177
Number of pages10
JournalOphthalmic Research
Volume27
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Timolol
Ocular Hypertension
Cross-Sectional Studies
Intraocular Pressure
Therapeutics
Reference Values
Hypertension
Pressure

Keywords

  • Intraocular pressure
  • Ocular hypertension
  • Pattern electroretinogram
  • Spatial frequency
  • Timolol maleate

ASJC Scopus subject areas

  • Ophthalmology
  • Cellular and Molecular Neuroscience
  • Sensory Systems

Cite this

Pattern electroretinogram in treated ocular hypertension : A cross-sectional study after timolol maleate therapy. / Colotto, A.; Salgarello, T.; Giudiceandrea, A.; De Luca, L. A.; Coppè, A.; Buzzonetti, L.; Falsini, B.

In: Ophthalmic Research, Vol. 27, No. 3, 1995, p. 168-177.

Research output: Contribution to journalArticle

Colotto, A, Salgarello, T, Giudiceandrea, A, De Luca, LA, Coppè, A, Buzzonetti, L & Falsini, B 1995, 'Pattern electroretinogram in treated ocular hypertension: A cross-sectional study after timolol maleate therapy', Ophthalmic Research, vol. 27, no. 3, pp. 168-177. https://doi.org/10.1159/000267663
Colotto, A. ; Salgarello, T. ; Giudiceandrea, A. ; De Luca, L. A. ; Coppè, A. ; Buzzonetti, L. ; Falsini, B. / Pattern electroretinogram in treated ocular hypertension : A cross-sectional study after timolol maleate therapy. In: Ophthalmic Research. 1995 ; Vol. 27, No. 3. pp. 168-177.
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