Pattern of lymphatic drainage to the sentinel lymph node in breast cancer patients

Giuseppe Canavese, Marco Gipponi, Alessandra Catturich, Carmine Di Somma, Carlo Vecchio, Francesco Rosato, Daniela Tomei, Guido Nicolò, Franca Carli, Giuseppe Villa, Giuseppe Agnese, Pietro Bianchi, Ferdinando Buffoni, Giuliano Mariani, Fausto Badellino

Research output: Contribution to journalArticle

Abstract

Background and Objective: We performed a pilot study on 30 consecutive patients undergoing sentinel node (sN) biopsy by radioguided surgery and vital blue dye mapping to determine whether there is a single sN for each breast independent of tumor site or an sN specifically related to the site of the breast neoplasm. Methods: There were 6 groups of 5 patients; each patient had a subdermal injection of radiotracer on the tumor site plus a second injection of radiotracer that was changed in every subset of patients to test whether modifying the site or the route of injection could have impaired the proper detection of the sN. Results: 'False' sN were detected only in patients who had a second injection of radiotracer away from the tumor site; this occurred in 2 of 5 patients (40%) in group I, in 3 of 5 patients (60%) in group II, in all patients in group III, and in 3 of 5 patients (60%) in group IV. The different route of injection (peritumoral or subdermal) always on the tumor site that was tested in groups V and VI did not impair the proper detection of the sN. Conclusions: Our findings support the hypothesis of a precise topographic correspondence between the primary tumor and its specific sN more than the existence of a first sN in the axillary basin, which indiscriminately drains all quadrants of the breast, like 'a neck of a bottle'. This should be considered for the proper selection of the injection site of either vital blue dye or radiopharmaceuticals. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJournal of Surgical Oncology
Volume74
Issue number1
DOIs
Publication statusPublished - 2000

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Keywords

  • Axillary lymph node dissection
  • Breast neoplasms
  • Lymphatic mapping
  • Staging

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Canavese, G., Gipponi, M., Catturich, A., Di Somma, C., Vecchio, C., Rosato, F., Tomei, D., Nicolò, G., Carli, F., Villa, G., Agnese, G., Bianchi, P., Buffoni, F., Mariani, G., & Badellino, F. (2000). Pattern of lymphatic drainage to the sentinel lymph node in breast cancer patients. Journal of Surgical Oncology, 74(1), 69-74. https://doi.org/10.1002/1096-9098(200005)74:1<69::AID-JSO15>3.0.CO;2-Z