Pattern of memory impairment in two patients with septohippocampal disconnection

S. Almonti, M. C. Silveri, G. Gainotti, G. Macchi

Research output: Contribution to journalArticlepeer-review


We describe two patients with lesions at different levels of the septo-hippocampal system. Both of them were selectively affected by anterograde amnesia, with a less severe retrograde amnesia. These data confirm that the integrity of the septo-hippocampal system is indispensable for the maintenance of normal memory and learning mechanisms and that the lesions along this fibre pathway, causing a functional and anatomic disconnection between the septal area (basal forebrain) and the medial temporal lobe structures, interfere with normal explicit memory functions.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalEuropean Journal of Neurology
Issue number4
Publication statusPublished - 1996


  • Amnesia
  • Learning
  • Septo-hippocampal disconnection

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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