We describe two patients with lesions at different levels of the septo-hippocampal system. Both of them were selectively affected by anterograde amnesia, with a less severe retrograde amnesia. These data confirm that the integrity of the septo-hippocampal system is indispensable for the maintenance of normal memory and learning mechanisms and that the lesions along this fibre pathway, causing a functional and anatomic disconnection between the septal area (basal forebrain) and the medial temporal lobe structures, interfere with normal explicit memory functions.
|Number of pages||8|
|Journal||European Journal of Neurology|
|Publication status||Published - 1996|
- Septo-hippocampal disconnection
ASJC Scopus subject areas
- Clinical Neurology