Patterning of cells in the Drosophila eye by lozenge, which shares homologous domains with AML1

A. Daga, C. A. Karlovich, K. Dumstrei, U. Banerjee

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

The lozenge (lz) gene encodes a transcription factor involved in prepatterning photoreceptor precursors in the developing Drosophila eye. The central region of the predicted Lz protein product is homologous to AML1, a transcription factor associated with human leukemias, and to the Drosophila protein Runt. We show here that Lz plays a crucial role in governing the fate of two groups of cells that are born in a single round of mitosis in the larval eye disc. Lz helps define a subset of these cells as an equipotential group that is competent to respond to the Sevenless developmental signal. This is achieved by negative regulation of seven-up, a member of the steroid hormone receptor superfamily in these cells. In contrast, in a second group of cells, the Lz protein confers proper photoreceptor identity by positively regulating the homeo box gene Bar. Additionally, our genetic analysis suggests that Lz interacts with the Ras pathway to determine photoreceptor cell fate. This study suggests that the strategies involved in cell fate determination in the Drosophila eye are remarkably similar to those utilized during vertebrate hematopoietic development and require the coordinate action of growth factor and AML1-like pathways.

Original languageEnglish
Pages (from-to)1194-1205
Number of pages12
JournalGenes and Development
Volume10
Issue number10
Publication statusPublished - May 15 1996

Fingerprint

Drosophila
Transcription Factors
Photoreceptor Cells
Steroid Receptors
Homeobox Genes
Mitosis
Vertebrates
Intercellular Signaling Peptides and Proteins
Leukemia
Proteins
Hormones
Genes

Keywords

  • AML1
  • Bar
  • Drosophila
  • eye development
  • neuronal differentiation
  • PEBP2α
  • Runt
  • Seven-up

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics

Cite this

Patterning of cells in the Drosophila eye by lozenge, which shares homologous domains with AML1. / Daga, A.; Karlovich, C. A.; Dumstrei, K.; Banerjee, U.

In: Genes and Development, Vol. 10, No. 10, 15.05.1996, p. 1194-1205.

Research output: Contribution to journalArticle

Daga, A, Karlovich, CA, Dumstrei, K & Banerjee, U 1996, 'Patterning of cells in the Drosophila eye by lozenge, which shares homologous domains with AML1', Genes and Development, vol. 10, no. 10, pp. 1194-1205.
Daga, A. ; Karlovich, C. A. ; Dumstrei, K. ; Banerjee, U. / Patterning of cells in the Drosophila eye by lozenge, which shares homologous domains with AML1. In: Genes and Development. 1996 ; Vol. 10, No. 10. pp. 1194-1205.
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