Patterning of the mammalian cochlea

Raquel Cantos, Laura K. Cole, Dario Acampora, Antonio Simeone, Doris K. Wu

Research output: Contribution to journalArticle


The mammalian cochlea is sophisticated in its function and highly organized in its structure. Although the anatomy of this sense organ has been well documented, the molecular mechanisms underlying its development have remained elusive. Information generated from mutant and knockout mice in recent years has increased our understanding of cochlear development and physiology. This article discusses factors important for the development of the inner ear and summarizes cochlear phenotypes of mutant and knockout mice, particularly Otx and Otx2. We also present data on gross development of the mouse cochlea.

Original languageEnglish
Pages (from-to)11707-11713
Number of pages7
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
Publication statusPublished - Oct 24 2000

ASJC Scopus subject areas

  • Genetics
  • General

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