Patterns and trends of transcatheter aortic valve implantation in Italy: insights from RISPEVA

Arturo Giordano, Nicola Corcione, Giuseppe Biondi-Zoccai, Sergio Berti, A. Sonia Petronio, C. Pierli, Patrizia Presbitero, P. Giudice, Gennaro Sardella, Antonio Bartorelli, Roberto Bonmassari, C. Indolfi, A. Marchese, Elvis Brscic, Alberto Cremonesi, Luca Testa, Nedy Brambilla, Francesco Bedogni

Research output: Contribution to journalArticle

Abstract

AIMS: Clinical trials have shown that transcatheter aortic valve implantation for aortic stenosis compares favorably to surgical replacement in high-risk patients and is superior to medical therapy in those at prohibitive risk. There is uncertainty however on patterns and trends in transcatheter aortic valve implantation, especially focusing on Italy. METHODS: The RISPEVA study is a prospective Italian registry including 21 institutions. Patients have been enrolled since late 2012, and data collection includes several baseline, procedural, in-hospital, and follow-up details. For the present analysis on patterns and trends, we focused on patients enrolled between 2012 and 2015, and as primary variable on the prevalence of high versus prohibitive surgical risk, limiting our scope to procedural outcomes. RESULTS: A total of 1157 patients were included. The temporal breakdown was 376 (33%) patients enrolled in 2013, 408 (35%) in 2014, and 373 (32%) in 2015. Several patient features differed over time, including risk score, peripheral artery disease, end-stage pulmonary disease, and prior valvuloplasty (all P?<?0.05). Several procedural features differed significantly over time, including sheath size, use of general anesthesia, Prostar closure device, predilation, antiembolic device, new TAVI device, and multiple prostheses (all P?<?0.05). No significant temporal differences were found for major clinical outcomes, whereas the occurrence of moderate or severe postprocedural regurgitation and pacemaker dependency decreased over the years (both P?<?0.05). CONCLUSION: According to the RISPEVA results, the Italian uptake of TAVI is steady, with evident trends toward less invasive approaches and fitter patients.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
DOIs
Publication statusAccepted/In press - Nov 24 2016

Fingerprint

Italy
Equipment and Supplies
Peripheral Arterial Disease
Aortic Valve Stenosis
Transcatheter Aortic Valve Replacement
General Anesthesia
Lung Diseases
Prostheses and Implants
Uncertainty
Registries
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Giordano, A., Corcione, N., Biondi-Zoccai, G., Berti, S., Petronio, A. S., Pierli, C., ... Bedogni, F. (Accepted/In press). Patterns and trends of transcatheter aortic valve implantation in Italy: insights from RISPEVA. Journal of Cardiovascular Medicine. https://doi.org/10.2459/JCM.0000000000000489

Patterns and trends of transcatheter aortic valve implantation in Italy : insights from RISPEVA. / Giordano, Arturo; Corcione, Nicola; Biondi-Zoccai, Giuseppe; Berti, Sergio; Petronio, A. Sonia; Pierli, C.; Presbitero, Patrizia; Giudice, P.; Sardella, Gennaro; Bartorelli, Antonio; Bonmassari, Roberto; Indolfi, C.; Marchese, A.; Brscic, Elvis; Cremonesi, Alberto; Testa, Luca; Brambilla, Nedy; Bedogni, Francesco.

In: Journal of Cardiovascular Medicine, 24.11.2016.

Research output: Contribution to journalArticle

Giordano, A, Corcione, N, Biondi-Zoccai, G, Berti, S, Petronio, AS, Pierli, C, Presbitero, P, Giudice, P, Sardella, G, Bartorelli, A, Bonmassari, R, Indolfi, C, Marchese, A, Brscic, E, Cremonesi, A, Testa, L, Brambilla, N & Bedogni, F 2016, 'Patterns and trends of transcatheter aortic valve implantation in Italy: insights from RISPEVA', Journal of Cardiovascular Medicine. https://doi.org/10.2459/JCM.0000000000000489
Giordano, Arturo ; Corcione, Nicola ; Biondi-Zoccai, Giuseppe ; Berti, Sergio ; Petronio, A. Sonia ; Pierli, C. ; Presbitero, Patrizia ; Giudice, P. ; Sardella, Gennaro ; Bartorelli, Antonio ; Bonmassari, Roberto ; Indolfi, C. ; Marchese, A. ; Brscic, Elvis ; Cremonesi, Alberto ; Testa, Luca ; Brambilla, Nedy ; Bedogni, Francesco. / Patterns and trends of transcatheter aortic valve implantation in Italy : insights from RISPEVA. In: Journal of Cardiovascular Medicine. 2016.
@article{00b05bc36f3a417bae708548df99e940,
title = "Patterns and trends of transcatheter aortic valve implantation in Italy: insights from RISPEVA",
abstract = "AIMS: Clinical trials have shown that transcatheter aortic valve implantation for aortic stenosis compares favorably to surgical replacement in high-risk patients and is superior to medical therapy in those at prohibitive risk. There is uncertainty however on patterns and trends in transcatheter aortic valve implantation, especially focusing on Italy. METHODS: The RISPEVA study is a prospective Italian registry including 21 institutions. Patients have been enrolled since late 2012, and data collection includes several baseline, procedural, in-hospital, and follow-up details. For the present analysis on patterns and trends, we focused on patients enrolled between 2012 and 2015, and as primary variable on the prevalence of high versus prohibitive surgical risk, limiting our scope to procedural outcomes. RESULTS: A total of 1157 patients were included. The temporal breakdown was 376 (33{\%}) patients enrolled in 2013, 408 (35{\%}) in 2014, and 373 (32{\%}) in 2015. Several patient features differed over time, including risk score, peripheral artery disease, end-stage pulmonary disease, and prior valvuloplasty (all P?<?0.05). Several procedural features differed significantly over time, including sheath size, use of general anesthesia, Prostar closure device, predilation, antiembolic device, new TAVI device, and multiple prostheses (all P?<?0.05). No significant temporal differences were found for major clinical outcomes, whereas the occurrence of moderate or severe postprocedural regurgitation and pacemaker dependency decreased over the years (both P?<?0.05). CONCLUSION: According to the RISPEVA results, the Italian uptake of TAVI is steady, with evident trends toward less invasive approaches and fitter patients.",
author = "Arturo Giordano and Nicola Corcione and Giuseppe Biondi-Zoccai and Sergio Berti and Petronio, {A. Sonia} and C. Pierli and Patrizia Presbitero and P. Giudice and Gennaro Sardella and Antonio Bartorelli and Roberto Bonmassari and C. Indolfi and A. Marchese and Elvis Brscic and Alberto Cremonesi and Luca Testa and Nedy Brambilla and Francesco Bedogni",
year = "2016",
month = "11",
day = "24",
doi = "10.2459/JCM.0000000000000489",
language = "English",
journal = "Journal of Cardiovascular Medicine",
issn = "1558-2027",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Patterns and trends of transcatheter aortic valve implantation in Italy

T2 - insights from RISPEVA

AU - Giordano, Arturo

AU - Corcione, Nicola

AU - Biondi-Zoccai, Giuseppe

AU - Berti, Sergio

AU - Petronio, A. Sonia

AU - Pierli, C.

AU - Presbitero, Patrizia

AU - Giudice, P.

AU - Sardella, Gennaro

AU - Bartorelli, Antonio

AU - Bonmassari, Roberto

AU - Indolfi, C.

AU - Marchese, A.

AU - Brscic, Elvis

AU - Cremonesi, Alberto

AU - Testa, Luca

AU - Brambilla, Nedy

AU - Bedogni, Francesco

PY - 2016/11/24

Y1 - 2016/11/24

N2 - AIMS: Clinical trials have shown that transcatheter aortic valve implantation for aortic stenosis compares favorably to surgical replacement in high-risk patients and is superior to medical therapy in those at prohibitive risk. There is uncertainty however on patterns and trends in transcatheter aortic valve implantation, especially focusing on Italy. METHODS: The RISPEVA study is a prospective Italian registry including 21 institutions. Patients have been enrolled since late 2012, and data collection includes several baseline, procedural, in-hospital, and follow-up details. For the present analysis on patterns and trends, we focused on patients enrolled between 2012 and 2015, and as primary variable on the prevalence of high versus prohibitive surgical risk, limiting our scope to procedural outcomes. RESULTS: A total of 1157 patients were included. The temporal breakdown was 376 (33%) patients enrolled in 2013, 408 (35%) in 2014, and 373 (32%) in 2015. Several patient features differed over time, including risk score, peripheral artery disease, end-stage pulmonary disease, and prior valvuloplasty (all P?<?0.05). Several procedural features differed significantly over time, including sheath size, use of general anesthesia, Prostar closure device, predilation, antiembolic device, new TAVI device, and multiple prostheses (all P?<?0.05). No significant temporal differences were found for major clinical outcomes, whereas the occurrence of moderate or severe postprocedural regurgitation and pacemaker dependency decreased over the years (both P?<?0.05). CONCLUSION: According to the RISPEVA results, the Italian uptake of TAVI is steady, with evident trends toward less invasive approaches and fitter patients.

AB - AIMS: Clinical trials have shown that transcatheter aortic valve implantation for aortic stenosis compares favorably to surgical replacement in high-risk patients and is superior to medical therapy in those at prohibitive risk. There is uncertainty however on patterns and trends in transcatheter aortic valve implantation, especially focusing on Italy. METHODS: The RISPEVA study is a prospective Italian registry including 21 institutions. Patients have been enrolled since late 2012, and data collection includes several baseline, procedural, in-hospital, and follow-up details. For the present analysis on patterns and trends, we focused on patients enrolled between 2012 and 2015, and as primary variable on the prevalence of high versus prohibitive surgical risk, limiting our scope to procedural outcomes. RESULTS: A total of 1157 patients were included. The temporal breakdown was 376 (33%) patients enrolled in 2013, 408 (35%) in 2014, and 373 (32%) in 2015. Several patient features differed over time, including risk score, peripheral artery disease, end-stage pulmonary disease, and prior valvuloplasty (all P?<?0.05). Several procedural features differed significantly over time, including sheath size, use of general anesthesia, Prostar closure device, predilation, antiembolic device, new TAVI device, and multiple prostheses (all P?<?0.05). No significant temporal differences were found for major clinical outcomes, whereas the occurrence of moderate or severe postprocedural regurgitation and pacemaker dependency decreased over the years (both P?<?0.05). CONCLUSION: According to the RISPEVA results, the Italian uptake of TAVI is steady, with evident trends toward less invasive approaches and fitter patients.

UR - http://www.scopus.com/inward/record.url?scp=85000786897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85000786897&partnerID=8YFLogxK

U2 - 10.2459/JCM.0000000000000489

DO - 10.2459/JCM.0000000000000489

M3 - Article

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

ER -