Patterns of care and survival in non small cell lung cancer: 15 years' experience in a general hospital

M. Clerici, D. Panvini, V. Torri, F. Colombo, G. Luporini, A. Tinazzi, A. Nicolucci, S. Marsoni

Research output: Contribution to journalArticle

Abstract

Background: Transferring results derived from clinical research into practice is particularly difficult in lung cancer where clear indications for treatment are defined only for selected subgroups of patients. Studies on hospital-based lung cancer population could provide data for quantifying this tissue. Patients and methods: This was a follow-up study of consecutive, first-diagnosis cases referred to the in- and outpatient cancer clinics of a large Italian general hospital between January 1975 and December 1990. Data were collected from medical records and recorded on ad hoc standardized forms. Analysis focused on changes in distribution over time of patient-related characteristics, prevalence of specific treatment strategies and survival of the study population. Results: 1345 primary non small cell lung cancer cases were reviewed and 1125 were fully evaluable. In early stages (510/1125, 45%) only 237 patients actually underwent surgery. In this group surgery increased from 36 to 69% whereas chemotherapy decreased from 58 to 15%. In the advanced group (615/1125, 55%) chemotherapy was the preferred treatment but combined modalities tripled over time (from 4 to 12%). No significant changes in survival were observed within each group over time. Conclusion: Despite changes in the therapeutic approaches, mortality from lung cancer does not seem reduced over time. Since the proportion of cases that could potentially benefit from 'active' treatments is small, for the large majority of patients a switch in clinical research from a cure to a careoriented strategy should be considered.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalTumori
Volume80
Issue number2
Publication statusPublished - 1994

Fingerprint

Non-Small Cell Lung Carcinoma
General Hospitals
Survival
Lung Neoplasms
Therapeutics
Drug Therapy
Ambulatory Care Facilities
Research
Population
Medical Records
Inpatients
Mortality
Neoplasms

Keywords

  • hospital-based population
  • lung neoplasm
  • pattern of care
  • survival

ASJC Scopus subject areas

  • Cancer Research

Cite this

Clerici, M., Panvini, D., Torri, V., Colombo, F., Luporini, G., Tinazzi, A., ... Marsoni, S. (1994). Patterns of care and survival in non small cell lung cancer: 15 years' experience in a general hospital. Tumori, 80(2), 106-112.

Patterns of care and survival in non small cell lung cancer : 15 years' experience in a general hospital. / Clerici, M.; Panvini, D.; Torri, V.; Colombo, F.; Luporini, G.; Tinazzi, A.; Nicolucci, A.; Marsoni, S.

In: Tumori, Vol. 80, No. 2, 1994, p. 106-112.

Research output: Contribution to journalArticle

Clerici, M, Panvini, D, Torri, V, Colombo, F, Luporini, G, Tinazzi, A, Nicolucci, A & Marsoni, S 1994, 'Patterns of care and survival in non small cell lung cancer: 15 years' experience in a general hospital', Tumori, vol. 80, no. 2, pp. 106-112.
Clerici M, Panvini D, Torri V, Colombo F, Luporini G, Tinazzi A et al. Patterns of care and survival in non small cell lung cancer: 15 years' experience in a general hospital. Tumori. 1994;80(2):106-112.
Clerici, M. ; Panvini, D. ; Torri, V. ; Colombo, F. ; Luporini, G. ; Tinazzi, A. ; Nicolucci, A. ; Marsoni, S. / Patterns of care and survival in non small cell lung cancer : 15 years' experience in a general hospital. In: Tumori. 1994 ; Vol. 80, No. 2. pp. 106-112.
@article{21e7ca8c94c54b9aa02bbdbee0b9c6d4,
title = "Patterns of care and survival in non small cell lung cancer: 15 years' experience in a general hospital",
abstract = "Background: Transferring results derived from clinical research into practice is particularly difficult in lung cancer where clear indications for treatment are defined only for selected subgroups of patients. Studies on hospital-based lung cancer population could provide data for quantifying this tissue. Patients and methods: This was a follow-up study of consecutive, first-diagnosis cases referred to the in- and outpatient cancer clinics of a large Italian general hospital between January 1975 and December 1990. Data were collected from medical records and recorded on ad hoc standardized forms. Analysis focused on changes in distribution over time of patient-related characteristics, prevalence of specific treatment strategies and survival of the study population. Results: 1345 primary non small cell lung cancer cases were reviewed and 1125 were fully evaluable. In early stages (510/1125, 45{\%}) only 237 patients actually underwent surgery. In this group surgery increased from 36 to 69{\%} whereas chemotherapy decreased from 58 to 15{\%}. In the advanced group (615/1125, 55{\%}) chemotherapy was the preferred treatment but combined modalities tripled over time (from 4 to 12{\%}). No significant changes in survival were observed within each group over time. Conclusion: Despite changes in the therapeutic approaches, mortality from lung cancer does not seem reduced over time. Since the proportion of cases that could potentially benefit from 'active' treatments is small, for the large majority of patients a switch in clinical research from a cure to a careoriented strategy should be considered.",
keywords = "hospital-based population, lung neoplasm, pattern of care, survival",
author = "M. Clerici and D. Panvini and V. Torri and F. Colombo and G. Luporini and A. Tinazzi and A. Nicolucci and S. Marsoni",
year = "1994",
language = "English",
volume = "80",
pages = "106--112",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Patterns of care and survival in non small cell lung cancer

T2 - 15 years' experience in a general hospital

AU - Clerici, M.

AU - Panvini, D.

AU - Torri, V.

AU - Colombo, F.

AU - Luporini, G.

AU - Tinazzi, A.

AU - Nicolucci, A.

AU - Marsoni, S.

PY - 1994

Y1 - 1994

N2 - Background: Transferring results derived from clinical research into practice is particularly difficult in lung cancer where clear indications for treatment are defined only for selected subgroups of patients. Studies on hospital-based lung cancer population could provide data for quantifying this tissue. Patients and methods: This was a follow-up study of consecutive, first-diagnosis cases referred to the in- and outpatient cancer clinics of a large Italian general hospital between January 1975 and December 1990. Data were collected from medical records and recorded on ad hoc standardized forms. Analysis focused on changes in distribution over time of patient-related characteristics, prevalence of specific treatment strategies and survival of the study population. Results: 1345 primary non small cell lung cancer cases were reviewed and 1125 were fully evaluable. In early stages (510/1125, 45%) only 237 patients actually underwent surgery. In this group surgery increased from 36 to 69% whereas chemotherapy decreased from 58 to 15%. In the advanced group (615/1125, 55%) chemotherapy was the preferred treatment but combined modalities tripled over time (from 4 to 12%). No significant changes in survival were observed within each group over time. Conclusion: Despite changes in the therapeutic approaches, mortality from lung cancer does not seem reduced over time. Since the proportion of cases that could potentially benefit from 'active' treatments is small, for the large majority of patients a switch in clinical research from a cure to a careoriented strategy should be considered.

AB - Background: Transferring results derived from clinical research into practice is particularly difficult in lung cancer where clear indications for treatment are defined only for selected subgroups of patients. Studies on hospital-based lung cancer population could provide data for quantifying this tissue. Patients and methods: This was a follow-up study of consecutive, first-diagnosis cases referred to the in- and outpatient cancer clinics of a large Italian general hospital between January 1975 and December 1990. Data were collected from medical records and recorded on ad hoc standardized forms. Analysis focused on changes in distribution over time of patient-related characteristics, prevalence of specific treatment strategies and survival of the study population. Results: 1345 primary non small cell lung cancer cases were reviewed and 1125 were fully evaluable. In early stages (510/1125, 45%) only 237 patients actually underwent surgery. In this group surgery increased from 36 to 69% whereas chemotherapy decreased from 58 to 15%. In the advanced group (615/1125, 55%) chemotherapy was the preferred treatment but combined modalities tripled over time (from 4 to 12%). No significant changes in survival were observed within each group over time. Conclusion: Despite changes in the therapeutic approaches, mortality from lung cancer does not seem reduced over time. Since the proportion of cases that could potentially benefit from 'active' treatments is small, for the large majority of patients a switch in clinical research from a cure to a careoriented strategy should be considered.

KW - hospital-based population

KW - lung neoplasm

KW - pattern of care

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=0028270640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028270640&partnerID=8YFLogxK

M3 - Article

C2 - 8016899

AN - SCOPUS:0028270640

VL - 80

SP - 106

EP - 112

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 2

ER -