Patterns of cognitive impairment in secondary progressive multiple sclerosis

U. Nocentini, P. M. Rossini, G. A. Carlesimo, A. Orlacchio, D. Lupoi, M. G. Grasso, B. Rizzato, C. Caltagirone

Research output: Contribution to journalArticlepeer-review


Many advances have been made in the last 15 years in the comprehension of the incidence, nature and clinicopathological correlation of the cognitive deficits in MS. Notwithstanding this, the debate on the features of this cognitive impairment is still open. Fortyfour patients affected by MS with a secondary progressive course were submitted to an exstensive neuropsychological evaluation. The scores obtained in the neuropsychological tests were analyzed in correlation with indexes of MR imaging and disability scores. The results show that cognitive deficits affecting patients with a chronic-progressive form of multiple sclerosis cluster in different profiles of cognitive performances and that the prevailing pattern of cognitive impairment (frontal lobe dysfunction ) does noi clearly correlate with indexes of regional lesion load but mainly with indexes of total lesion load and brain atrophy.

Original languageEnglish
Pages (from-to)53
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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