Patterns of motor control reorganization in a patient with mirror movements

P. Balbi, L. Trojano, M. Ragno, A. Perretti, L. Santoro

Research output: Contribution to journalArticle

Abstract

Objective: To explore motor control reorganization in a 40-year-old, left-handed patient with perinatally acquired mirror movements.Methods: We performed simultaneous bilateral recordings of motor evoked potentials (MEPs) following focal transcranial magnetic stimulation (fTMS) and of central silent period (cSP) during unilateral voluntary contraction in abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles.Results: For both muscles the MEP study showed bilateral fast-conducting corticospinal projections from the right undamaged hemisphere, and residual contralateral projections from the left hemisphere. The cSP findings differed in the two muscles: the mirror phenomenon was bilateral in the ADM, but present only on the right side in the APB muscles; the mirror activity of right ADM and APB muscles was inhibited only by fTMS of the ipsilateral right motor cortex; the mirror phenomenon in the left ADM muscle was inhibited only by fTMS of the contralateral right motor cortex.Conclusions: Mirror movements of right APB and ADM muscles were sustained by the ipsilateral connections from the undamaged motor cortex, while the mirror phenomenon in the left ADM muscle could be explained by hypothesizing a bilateral activation of motor cortices. This previously unreported electrophysiological picture demonstrates that different patterns of motor control may realize after perinatal cerebral lesions, even in different distal muscles of the same patient. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalClinical Neurophysiology
Volume111
Issue number2
DOIs
Publication statusPublished - Feb 1 2000

Fingerprint

Muscles
Motor Cortex
Transcranial Magnetic Stimulation
Motor Evoked Potentials

Keywords

  • Mirror movements
  • Motor control
  • Motor evoked potentials
  • Perinatal cerebral lesion
  • Silent period

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Patterns of motor control reorganization in a patient with mirror movements. / Balbi, P.; Trojano, L.; Ragno, M.; Perretti, A.; Santoro, L.

In: Clinical Neurophysiology, Vol. 111, No. 2, 01.02.2000, p. 318-325.

Research output: Contribution to journalArticle

Balbi, P. ; Trojano, L. ; Ragno, M. ; Perretti, A. ; Santoro, L. / Patterns of motor control reorganization in a patient with mirror movements. In: Clinical Neurophysiology. 2000 ; Vol. 111, No. 2. pp. 318-325.
@article{795847bad78a4aa495300a818e1ffbca,
title = "Patterns of motor control reorganization in a patient with mirror movements",
abstract = "Objective: To explore motor control reorganization in a 40-year-old, left-handed patient with perinatally acquired mirror movements.Methods: We performed simultaneous bilateral recordings of motor evoked potentials (MEPs) following focal transcranial magnetic stimulation (fTMS) and of central silent period (cSP) during unilateral voluntary contraction in abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles.Results: For both muscles the MEP study showed bilateral fast-conducting corticospinal projections from the right undamaged hemisphere, and residual contralateral projections from the left hemisphere. The cSP findings differed in the two muscles: the mirror phenomenon was bilateral in the ADM, but present only on the right side in the APB muscles; the mirror activity of right ADM and APB muscles was inhibited only by fTMS of the ipsilateral right motor cortex; the mirror phenomenon in the left ADM muscle was inhibited only by fTMS of the contralateral right motor cortex.Conclusions: Mirror movements of right APB and ADM muscles were sustained by the ipsilateral connections from the undamaged motor cortex, while the mirror phenomenon in the left ADM muscle could be explained by hypothesizing a bilateral activation of motor cortices. This previously unreported electrophysiological picture demonstrates that different patterns of motor control may realize after perinatal cerebral lesions, even in different distal muscles of the same patient. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Mirror movements, Motor control, Motor evoked potentials, Perinatal cerebral lesion, Silent period",
author = "P. Balbi and L. Trojano and M. Ragno and A. Perretti and L. Santoro",
year = "2000",
month = "2",
day = "1",
doi = "10.1016/S1388-2457(99)00239-4",
language = "English",
volume = "111",
pages = "318--325",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Patterns of motor control reorganization in a patient with mirror movements

AU - Balbi, P.

AU - Trojano, L.

AU - Ragno, M.

AU - Perretti, A.

AU - Santoro, L.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - Objective: To explore motor control reorganization in a 40-year-old, left-handed patient with perinatally acquired mirror movements.Methods: We performed simultaneous bilateral recordings of motor evoked potentials (MEPs) following focal transcranial magnetic stimulation (fTMS) and of central silent period (cSP) during unilateral voluntary contraction in abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles.Results: For both muscles the MEP study showed bilateral fast-conducting corticospinal projections from the right undamaged hemisphere, and residual contralateral projections from the left hemisphere. The cSP findings differed in the two muscles: the mirror phenomenon was bilateral in the ADM, but present only on the right side in the APB muscles; the mirror activity of right ADM and APB muscles was inhibited only by fTMS of the ipsilateral right motor cortex; the mirror phenomenon in the left ADM muscle was inhibited only by fTMS of the contralateral right motor cortex.Conclusions: Mirror movements of right APB and ADM muscles were sustained by the ipsilateral connections from the undamaged motor cortex, while the mirror phenomenon in the left ADM muscle could be explained by hypothesizing a bilateral activation of motor cortices. This previously unreported electrophysiological picture demonstrates that different patterns of motor control may realize after perinatal cerebral lesions, even in different distal muscles of the same patient. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - Objective: To explore motor control reorganization in a 40-year-old, left-handed patient with perinatally acquired mirror movements.Methods: We performed simultaneous bilateral recordings of motor evoked potentials (MEPs) following focal transcranial magnetic stimulation (fTMS) and of central silent period (cSP) during unilateral voluntary contraction in abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles.Results: For both muscles the MEP study showed bilateral fast-conducting corticospinal projections from the right undamaged hemisphere, and residual contralateral projections from the left hemisphere. The cSP findings differed in the two muscles: the mirror phenomenon was bilateral in the ADM, but present only on the right side in the APB muscles; the mirror activity of right ADM and APB muscles was inhibited only by fTMS of the ipsilateral right motor cortex; the mirror phenomenon in the left ADM muscle was inhibited only by fTMS of the contralateral right motor cortex.Conclusions: Mirror movements of right APB and ADM muscles were sustained by the ipsilateral connections from the undamaged motor cortex, while the mirror phenomenon in the left ADM muscle could be explained by hypothesizing a bilateral activation of motor cortices. This previously unreported electrophysiological picture demonstrates that different patterns of motor control may realize after perinatal cerebral lesions, even in different distal muscles of the same patient. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Mirror movements

KW - Motor control

KW - Motor evoked potentials

KW - Perinatal cerebral lesion

KW - Silent period

UR - http://www.scopus.com/inward/record.url?scp=0033987208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033987208&partnerID=8YFLogxK

U2 - 10.1016/S1388-2457(99)00239-4

DO - 10.1016/S1388-2457(99)00239-4

M3 - Article

C2 - 10680568

AN - SCOPUS:0033987208

VL - 111

SP - 318

EP - 325

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 2

ER -