Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG.

Winan J. van Houdt, Marco Fiore, Francesco Barretta, Piotr Rutkowski, Jean-Yves Blay, Guy Lahat, Dirk Strauss, Ricardo J. Gonzalez, Nita Ahuja, Giovanni Grignani, Vittorio Quagliuolo, Eberhard Stoeckle, Antonino De Paoli, Yvonne Schrage, Kenneth Cardona, Elisabetta Pennacchioli, Venu G. Pillarisetty, Carolyn Nessim, Carol J. Swallow, Sanjay P. BagariaRobert Canter, John T. Mullen, Dario Callegaro, Mark Fairweather, Rosalba Miceli, Chandrajit P. Raut, Alessandro Gronchi, Rebecca A. Gladdy

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BACKGROUND: In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR). METHODS: Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence. RESULTS: Second recurrences occurred in 400 of 567 patients (70.5 after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75, distant metastases (DM) in 55 patients (13.75, and both LR and DM in 22 patients (5.5. The main subtype among the LR group was liposarcoma (77, whereas DM mainly were leiomyosarcomas (43.6. In patients with a second LR only, a total of 200 patients underwent re-resection (61.9. The 5-year OS rate varied significantly based on the pattern of failure (P textless .001): 45.6 25.5 and 032 months vs 8 months: hazard ratio, 0.44 [P textless .001]) and surgery for second recurrence (yes vs no: hazard ratio, 3.25 [P textless .001]). The 5-year OS rate for patients undergoing surgery for a second LR was 598 Survival rates after second recurrence of RPS varied based on patterns of disease recurrence and treatment. Durable disease-free survivors were identified after surgery for second LR in patients selected for this intervention.
Original languageEnglish
Issue number22
Publication statusPublished - Nov 1 2020


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