Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG

W.J. van Houdt, M. Fiore, F. Barretta, P. Rutkowski, J.-Y. Blay, G. Lahat, D. Strauss, R.J. Gonzalez, N. Ahuja, G. Grignani, V. Quagliuolo, E. Stoeckle, A. De Paoli, Y. Schrage, K. Cardona, E. Pennacchioli, V.G. Pillarisetty, C. Nessim, C.J. Swallow, S.P. BagariaR. Canter, J.T. Mullen, D. Callegaro, M. Fairweather, R. Miceli, C.P. Raut, A. Gronchi, R.A. Gladdy

Research output: Contribution to journalArticlepeer-review


Background: In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR). Methods: Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence. Results: Second recurrences occurred in 400 of 567 patients (70.5%) after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75%), distant metastases (DM) in 55 patients (13.75%), and both LR and DM in 22 patients (5.5%). The main subtype among the LR group was liposarcoma (77%), whereas DM mainly were leiomyosarcomas (43.6%). In patients with a second LR only, a total of 200 patients underwent re-resection (61.9%). The 5-year OS rate varied significantly based on the pattern of failure (P 
Original languageEnglish
Pages (from-to)4917-4925
Number of pages9
Issue number22
Publication statusPublished - 2020


  • leiomyosarcoma
  • liposarcoma
  • recurrence
  • retroperitoneal sarcoma
  • adult
  • aged
  • Article
  • cancer chemotherapy
  • cancer classification
  • cancer radiotherapy
  • cancer recurrence
  • cancer survival
  • controlled study
  • dedifferentiated liposarcoma
  • disease free survival
  • distant metastasis
  • female
  • follow up
  • histopathology
  • human
  • human tissue
  • major clinical study
  • male
  • malignant fibrous histiocytoma cell line
  • middle aged
  • overall survival
  • peripheral nerve tumor
  • priority journal
  • probability
  • solitary fibrous tumor
  • survival rate
  • well differentiated liposarcoma


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