Paucisymptomatic Marchiafava-Bignami disease with relevant diffusion-weighted MRI lesions

Maria Giovanna Sarpa, Davide Ferrazzoli, Roberto Massa, Francesco Garaci, Francesca Izzi, Andrea Romigi, Claudio Liguori, Fabio Placidi

Research output: Contribution to journalArticlepeer-review


Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelization and necrosis of the corpus callosum. Diffusion-weighted (DW) MRI may reveal the lesions in patients showing serious clinical manifestations, high mortality rate and severe cognitive sequelae, though some cases with good outcome have been reported. We describe a case of a man with a history of chronic alcohol abuse associated with malabsorption; the man presented mild clinical signs on the first neurological exam, despite the presence of DW-MRI lesions, bilaterally involving entire corpus callosum, that are compatible with MBD diagnosis.

Original languageEnglish
Pages (from-to)738-740
Number of pages3
JournalInternational Journal of Neuroscience
Issue number10
Publication statusPublished - Oct 2013


  • Alcohol abuse
  • Diffusion-weighted MRI
  • Malabsorption
  • Marchiafava-Bignami disease
  • Outcome
  • Prognosis

ASJC Scopus subject areas

  • Neuroscience(all)


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