PB: PRM ratio in patients with epilepsy treated with primidone

C. M. Cornaggia, A. C. Altamura, M. Bianchi, R. Canger, P. Polana, C. Pruneri

Research output: Contribution to journalArticle

Abstract

Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients in both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA). A correlation was observed between the dose and the levels of both PRM and PB. Plasma PB:PRM ratio was highly variable, especially interindividually. These changes seemed to be linked to age and particularly to pharmacological associations. In fact, the PB:PRM ratio was increased with CBZ, ESM, VPA and PHT. Moreover, a correlation was observed between the PB:PRM ratio and PHT plasma levels. The possibility of monitoring PB and PRM plasma levels during long-term treatment with PRM is discussed.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalInternational Journal of Clinical Pharmacology Research
Volume3
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Cornaggia, C. M., Altamura, A. C., Bianchi, M., Canger, R., Polana, P., & Pruneri, C. (1983). PB: PRM ratio in patients with epilepsy treated with primidone. International Journal of Clinical Pharmacology Research, 3(3), 185-193.