Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients in both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA). A correlation was observed between the dose and the levels of both PRM and PB. Plasma PB:PRM ratio was highly variable, especially interindividually. These changes seemed to be linked to age and particularly to pharmacological associations. In fact, the PB:PRM ratio was increased with CBZ, ESM, VPA and PHT. Moreover, a correlation was observed between the PB:PRM ratio and PHT plasma levels. The possibility of monitoring PB and PRM plasma levels during long-term treatment with PRM is discussed.
|Number of pages||9|
|Journal||International Journal of Clinical Pharmacology Research|
|Publication status||Published - 1983|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)