PC12 interaction with magnetic Nanotubes: Effects on viability, cell differentiation and cell translocation induced by a magnetic field

Orazio Vittorio, Vittoria Raffa, Cristina Riggio, Andrea Pietrabissa, Alfred Cuschieri

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper we used Multi Wall Carbon Nanotubes (MWCNTs) containing 3% of residuals and impurities of Fe, Al, and Zn. MWCNTs, by virtue of Fe at their tips, are able to respond to the effects of external magnetic fields. We demonstrated that MWCNTs interact with PC12 cells without compromising their viability and differentiation with outgrowth of neurites. We also document that when exposed to a magnetic field, both undifferentiated and differentiated PC12 cells cultured in CNT-containing medium solution are able to move towards the magnetic source.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalCurrent Nanoscience
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Cell displacement
  • Magnetic materials
  • Nanoparticles
  • Neuronal differentiation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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