PCA3 score of 20 could improve prostate cancer detection: Results obtained on 734 Italian individuals

Ettore Capoluongo, Carlo Federico Zambon, Daniela Basso, Stefania Boccia, Sandro Rocchetti, Emanuele Leoncini, Sara Palumbo, Andrea Padoan, Giuseppe Albino, Angelo Todaro, Tommaso Prayer-Galetti, Filiberto Zattoni, Cecilia Zuppi, Mario Plebani

Research output: Contribution to journalArticle


Background: The role of PCa3 score in the diagnostics of prostate cancer (PCa) is still under debate, mainly due to the lack of a univocal cut-off useful alone or within nomograms proposed by Urologists. Aim of present study is to compare different PCA3 score cut-off values (20, 25, 35 and 50) observed in 734 patients with suspected PCa who were monitored for about three years with single or multiple biopsies. Methods: 734 patients who underwent first prostate biopsy for suspected PCa were enrolled. One month later the first biopsy result was obtained, both negative and positive PCa patients were investigated by means of PCA3 score, in order to establish risk of PCa presence on repeated biopsies. Results: PCA3 score was significantly higher (p.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalClinica Chimica Acta
Publication statusPublished - Feb 15 2014



  • PCa
  • PCA3 score
  • Progensa

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Capoluongo, E., Zambon, C. F., Basso, D., Boccia, S., Rocchetti, S., Leoncini, E., Palumbo, S., Padoan, A., Albino, G., Todaro, A., Prayer-Galetti, T., Zattoni, F., Zuppi, C., & Plebani, M. (2014). PCA3 score of 20 could improve prostate cancer detection: Results obtained on 734 Italian individuals. Clinica Chimica Acta, 429, 46-50. https://doi.org/10.1016/j.cca.2013.10.022