PCL loaded with sol-gel synthesized organic-inorganic hybrid fillers: From the analysis of 2D substrates to the design of 3D rapid prototyped composite scaffolds for tissue engineering

R. De Santis, A. Gloria, T. Russo, U. D'Amora, V. D'Antò, F. Bollino, M. Catauro, F. Mollica, S. Rengo, L. Ambrosio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

As reported in the literature, scaffolds for soft and hard tissue regeneration should satisfy several requirements. In the present work, the potential of 3D fiber deposition technique to design morphologically controlled scaffolds consisting of poly(ε-caprolactone) reinforced with sol-gel synthesized organic-inorganic hybrid fillers was demonstrated, also benefiting from a basic study carried out on 2D composite substrates. Finite element analysis, biological and mechanical tests were properly performed to assess the effects of the inclusion of the hybrid fillers on the performances of 2D substrates and 3D structures.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages26-29
Number of pages4
Volume1459
Edition1
DOIs
Publication statusPublished - 2012
Event6th International Conference on Times of Polymers (TOP) and Composites - Ischia, Italy
Duration: Jun 10 2012Jun 14 2012

Other

Other6th International Conference on Times of Polymers (TOP) and Composites
CountryItaly
CityIschia
Period6/10/126/14/12

Keywords

  • Alamar Blue™ assay
  • Composite scaffolds
  • Finite element analysis
  • Mechanical properties
  • Organic-inorganic hybrid
  • Poly(e-caprolactone)
  • Tissue engineering

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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