Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex. One of the well-established functions for PCNA is its role as the processing factor for DNA polymerase δ and ε. It has become apparent that PCNA interacts with proteins involved in the cell cycle. The PCNA interactions with different cellular proteins and the importance of these interactions are also discussed. To examine the different mitotic testicular epithelium proliferation during the annual discontinuous frog (Rana esculenta) spermatogenesis, the temporal and the spatial PCNA expression are described and give a useful endogenous molecular marker. (C) 2000 Academic Press.
- Cell cycle
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