PCR analysis of HBV infected sera: relationship between expression of pre-S antigens and viral replication.

A. R. Garbuglia, A. Manzin, A. Budkowska, G. Taliani, C. Delfini, G. Carloni

Research output: Contribution to journalArticle

Abstract

In order to determine the biological significance of the pre-S antigens in HBV infection, HBsAg sera were tested for the presence of pre-S1 and pre-S2. HBV DNA was detected by spot-hybridization and PCR. The data show a complete correlation between pre-S antigenemia and HBV DNA replication in anti-HBe positive cases. PCR but not spot-hybridization was adequately sensitive to also detect HBV DNA in roughly half of the preS negative sera as well. Thus PCR appears to be a valuable technique for detection of potentially infectious anti-HBe carriers.

Original languageEnglish
Pages (from-to)113-115
Number of pages3
JournalArchives of virology. Supplementum
Volume4
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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