PCSK-9 Inhibitors in a Real-World Setting and a Comparison between Alirocumab and Evolocumab in Heterozygous FH Patients

José Juan Ceballos-Macías, Carolina Lara-Sánchez, Jorge Flores-Real, Carlos Alberto Aguilar-Salinas, Guillermo Ortega-Gutiérrez, Joel Vargas-Sánchez, Ramón Madriz-Prado, Giuseppe Derosa, Hazel Rodríguez-Benítez, Ricardo Baltazar-Romero, Dante José Lopez-Mezquita

Research output: Contribution to journalArticlepeer-review

Abstract

A real-world setting study of familial hypercholesterolemia (FH) patients who received Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in a specialized referral center in Mexico City. Ten patients between the ages of 18 and 70 years, with a diagnosis of FH according to Dutch Lipid Clinic Network (DLCN) criteria, with failure to achieve their Low-density lipoprotein Cholesterol (LDL-C) goals, and with standard therapy between 2016 and 2017 enrolled in a simple randomization in which a group of 5 participants received alirocumab (75 mg every 2 weeks) and the remaining 5 patients received evolocumab (140 mg every 2 weeks). Comparative analysis was made, analyzing the means of LDL at baseline at 4, 6, and 12 weeks. The evolocumab group had an average initial LDL-C of 277 mg/dL, which, after 12 weeks of treatment, was significantly reduced to 116 mg/dL; P = 0.04 (95% confidence interval [CI]: 11.5-310.9). The alirocumab group with a mean initial LDL-C of 229 mg/dL showed a reduction of LDL-C levels at 12 weeks of treatment to 80 mg/dL; P = 0.008 (95% CI: 63.8-233.7). In conclusion, PCSK9 inhibitors are an excellent treatment option in patients with FH who do not reach their LDL-C goals with standard therapy or due to intolerance to the standard therapy. There is no difference in the lipid-lowering effect between both PSCK9 inhibitors.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of the Endocrine Society
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • alirocumab
  • evolocumab
  • PCSK9 inhibitors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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