PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion

Simona Urbani, Barbara Amadei, Daniela Tola, Marco Massari, Simona Schivazappa, Gabriele Missale, Carlo Ferrari

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CDS cells expressed PD-1 at the time of acute illness, irrespective of the final outcome. PD-1 expression declined with the acquisition of a memory phenotype and recovery of an efficient CDS cell function in resolving HCV infections, whereas high levels were maintained when HCV persisted and HCV-specific CDS cells remained dysfunctional. Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells.

Original languageEnglish
Pages (from-to)11398-11403
Number of pages6
JournalJournal of Virology
Volume80
Issue number22
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Immunology

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    Urbani, S., Amadei, B., Tola, D., Massari, M., Schivazappa, S., Missale, G., & Ferrari, C. (2006). PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. Journal of Virology, 80(22), 11398-11403. https://doi.org/10.1128/JVI.01177-06