PD-L1 immunohistochemical detection in tumor cells and tumor microenvironment: Main considerations on the use of tissue micro arrays

Research output: Contribution to journalComment/debatepeer-review

Abstract

PD-1/PD-L1 (programmed death 1/programmed death ligand 1) pathway plays a critical role in immune escape of tumor cells. Recent studies have described that PD-L1 is heterogeneously expressed in various types of cancer, although its prognostic/predictive value is still uncertain. These problems are partly due to a not well defined operating protocol for its detection by immunohistochemistry, but also because most of the studies conducted on large case series were made by Tissue Micro Array (TMA).We are going to discuss this latter point, to highlight that TMA must be set up in an appropriate manner, especially for some markers, such as PD-L1, which, besides being poorly expressed in tumor cells, can be expressed by cells of the tumor microenvironment.

Original languageEnglish
Article number1046
JournalInternational Journal of Molecular Sciences
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • PD-L1 immunohistochemical (IHC) detection
  • TMA
  • Tumor microenvironment

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Fingerprint Dive into the research topics of 'PD-L1 immunohistochemical detection in tumor cells and tumor microenvironment: Main considerations on the use of tissue micro arrays'. Together they form a unique fingerprint.

Cite this