Pearl and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability—part II

M. de Tommaso, V. Betti, T. Bocci, N. Bolognini, F. Di Russo, F. Fattapposta, R. Ferri, S. Invitto, G. Koch, C. Miniussi, F. Piccione, A. Ragazzoni, F. Sartucci, S. Rossi, M. Valeriani

Research output: Contribution to journalArticlepeer-review


This review focuses on new and/or less standardized event-related potentials methods, in order to improve their knowledge for future clinical applications. The olfactory event-related potentials (OERPs) assess the olfactory functions in time domain, with potential utility in anosmia and degenerative diseases. The transcranial magnetic stimulation-electroencephalography (TMS-EEG) could support the investigation of the intracerebral connections with very high temporal discrimination. Its application in the diagnosis of disorders of consciousness has achieved recent confirmation. Magnetoencephalography (MEG) and event-related fields (ERF) could improve spatial accuracy of scalp signals, with potential large application in pre-surgical study of epileptic patients. Although these techniques have methodological limits, such as high inter- and intraindividual variability and high costs, their diffusion among researchers and clinicians is hopeful, pending their standardization.

Original languageItalian
Pages (from-to)3503-3515
Number of pages13
JournalNeurological Sciences
Issue number12
Publication statusPublished - 2020

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