PEComa

Another member of the MiT tumor family?

Alberto Righi, Kypros Dimosthenous, Juan Rosai

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We report 2 cases of PEComa, one occurring in the colon of an 11-year-old boy and the other in the bone (fibula) of a 92-year-old woman. Both tumors consisted of nests of large epithelioid cells surrounded by a fibrovascular stroma. The nuclei were large and vesicular, with prominent centrally located nucleoli. The cytoplasm was eosinophilic, with a fine to coarse granularity. Mitoses and individual cell necrosis were infrequent. Immunohistochemically, both tumors showed strong cytoplasmic expression of HMB-45 and intense nuclear positivity for TFE3. To our knowledge, nuclear positivity for TFE3 has been previously reported in only 5 cases of PEComa. Reactivity to this marker suggests that PEComa should be added to the growing list of human tumors of the so-called MiT family gene.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalInternational Journal of Surgical Pathology
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Perivascular Epithelioid Cell Neoplasms
Epithelioid Cells
Neoplasms
Fibula
Mitosis
Colon
Cytoplasm
Necrosis
Bone and Bones
Genes

Keywords

  • Malignant tumor
  • MiT tumor family
  • PEComa

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

PEComa : Another member of the MiT tumor family? / Righi, Alberto; Dimosthenous, Kypros; Rosai, Juan.

In: International Journal of Surgical Pathology, Vol. 16, No. 1, 01.2008, p. 16-20.

Research output: Contribution to journalArticle

Righi, Alberto ; Dimosthenous, Kypros ; Rosai, Juan. / PEComa : Another member of the MiT tumor family?. In: International Journal of Surgical Pathology. 2008 ; Vol. 16, No. 1. pp. 16-20.
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