Peculiare presentazione clinica della sindrome di Lennox-Gastaut in pazienti con trisomia 21

Translated title of the contribution: Peculiar clinical features of Lennox-Gastaut syndrome in trisomy 21 patients

D. Italiano, E. Ferlazzo, C. K. Adjien, R. Guerrini, M. Elia, P. Striano, A. Crespel, T. Calarese, P. Bramanti, P. Di Bella, P. Gelisse, P. Genton

Research output: Contribution to journalArticlepeer-review

Abstract

Lennox-Gastaut syndrome (LGS) has been rarely and incompletely described in subjects with Down syndrome (DS). We retrospectively collected the clinical and EEG data of 13 consecutive patients with LGS and DS referred to 4 epilepsy centres over the last 20 years. The mean age at onset was 9.09 years (range 5-16). There were no patients with seizure onset before the age of 5 years, 5 patients (38%) with seizure onset between 5 and 8 years,while 8 patients (61%) had seizures onset after age 8.Nine patients (69%) had unambiguous reflex seizures mostly precipitated by sudden unexpected sensory stimulations, usually preceding or accompanying the onset of full-blown LGS picture. Interictal and ictal EEG findings were typical for LGS.All patients were drugresistant. Our data suggest that patients with DS may present a peculiar LGS characterized by late onset and high occurrence of reflex seizures.

Translated title of the contributionPeculiar clinical features of Lennox-Gastaut syndrome in trisomy 21 patients
Original languageItalian
Pages (from-to)167-168
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number138
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Peculiar clinical features of Lennox-Gastaut syndrome in trisomy 21 patients'. Together they form a unique fingerprint.

Cite this