Pediatric Acute Kidney Injury

Tiziana Fragasso, Zaccaria Ricci, Stuart L Goldstein

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Acute kidney injury (AKI) in children is a serious condition with an important impact on morbidity and mortality. Onset can be insidious and it is frequently unrecognized in the early phase when the therapeutic opportunities are theoretically more effective.

SUMMARY: The present review focuses on the most recent epidemiology studies and the progress in pediatric AKI (pAKI) research. Standardization of definition (presented in the Kidney Disease: Improving Global Outcomes) and novel biomarkers have been developed to help clinicians recognize kidney injury in a timely manner, both in adult and pediatric populations. Strengths and weaknesses of these diagnostic tools are discussed and the clinical scoring system (Renal Angina Index), which aims to provide a rational context for biomarker utilization, is also presented. Even if effective treatments are not currently available for established AKI, specific preventive approaches and some promising pharmacological treatments will be detailed. Renal replacement therapy is currently considered the most effective way to manage fluid balance when severe AKI occurs. Key Messages: Great efforts in pAKI research have today led to new strategies for early AKI detection and prevention strategies. Further studies have to be conducted in the next future in order to definitely improve the outcomes of pediatric patients experiencing this deadly syndrome.

Original languageEnglish
Pages (from-to)113-126
Number of pages14
JournalContributions to Nephrology
Volume193
DOIs
Publication statusPublished - 2018

Fingerprint

Acute Kidney Injury
Pediatrics
Biomarkers
Kidney
Water-Electrolyte Balance
Renal Replacement Therapy
Kidney Diseases
Research
Epidemiology
Therapeutics
Pharmacology
Morbidity
Mortality
Wounds and Injuries
Population

Cite this

Pediatric Acute Kidney Injury. / Fragasso, Tiziana; Ricci, Zaccaria; Goldstein, Stuart L.

In: Contributions to Nephrology, Vol. 193, 2018, p. 113-126.

Research output: Contribution to journalArticle

Fragasso, Tiziana ; Ricci, Zaccaria ; Goldstein, Stuart L. / Pediatric Acute Kidney Injury. In: Contributions to Nephrology. 2018 ; Vol. 193. pp. 113-126.
@article{6c2cddff1188435dad153acb63ba84da,
title = "Pediatric Acute Kidney Injury",
abstract = "BACKGROUND: Acute kidney injury (AKI) in children is a serious condition with an important impact on morbidity and mortality. Onset can be insidious and it is frequently unrecognized in the early phase when the therapeutic opportunities are theoretically more effective.SUMMARY: The present review focuses on the most recent epidemiology studies and the progress in pediatric AKI (pAKI) research. Standardization of definition (presented in the Kidney Disease: Improving Global Outcomes) and novel biomarkers have been developed to help clinicians recognize kidney injury in a timely manner, both in adult and pediatric populations. Strengths and weaknesses of these diagnostic tools are discussed and the clinical scoring system (Renal Angina Index), which aims to provide a rational context for biomarker utilization, is also presented. Even if effective treatments are not currently available for established AKI, specific preventive approaches and some promising pharmacological treatments will be detailed. Renal replacement therapy is currently considered the most effective way to manage fluid balance when severe AKI occurs. Key Messages: Great efforts in pAKI research have today led to new strategies for early AKI detection and prevention strategies. Further studies have to be conducted in the next future in order to definitely improve the outcomes of pediatric patients experiencing this deadly syndrome.",
author = "Tiziana Fragasso and Zaccaria Ricci and Goldstein, {Stuart L}",
note = "{\circledC} 2018 S. Karger AG, Basel.",
year = "2018",
doi = "10.1159/000484968",
language = "English",
volume = "193",
pages = "113--126",
journal = "Contributions to Nephrology",
issn = "0302-5144",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Pediatric Acute Kidney Injury

AU - Fragasso, Tiziana

AU - Ricci, Zaccaria

AU - Goldstein, Stuart L

N1 - © 2018 S. Karger AG, Basel.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Acute kidney injury (AKI) in children is a serious condition with an important impact on morbidity and mortality. Onset can be insidious and it is frequently unrecognized in the early phase when the therapeutic opportunities are theoretically more effective.SUMMARY: The present review focuses on the most recent epidemiology studies and the progress in pediatric AKI (pAKI) research. Standardization of definition (presented in the Kidney Disease: Improving Global Outcomes) and novel biomarkers have been developed to help clinicians recognize kidney injury in a timely manner, both in adult and pediatric populations. Strengths and weaknesses of these diagnostic tools are discussed and the clinical scoring system (Renal Angina Index), which aims to provide a rational context for biomarker utilization, is also presented. Even if effective treatments are not currently available for established AKI, specific preventive approaches and some promising pharmacological treatments will be detailed. Renal replacement therapy is currently considered the most effective way to manage fluid balance when severe AKI occurs. Key Messages: Great efforts in pAKI research have today led to new strategies for early AKI detection and prevention strategies. Further studies have to be conducted in the next future in order to definitely improve the outcomes of pediatric patients experiencing this deadly syndrome.

AB - BACKGROUND: Acute kidney injury (AKI) in children is a serious condition with an important impact on morbidity and mortality. Onset can be insidious and it is frequently unrecognized in the early phase when the therapeutic opportunities are theoretically more effective.SUMMARY: The present review focuses on the most recent epidemiology studies and the progress in pediatric AKI (pAKI) research. Standardization of definition (presented in the Kidney Disease: Improving Global Outcomes) and novel biomarkers have been developed to help clinicians recognize kidney injury in a timely manner, both in adult and pediatric populations. Strengths and weaknesses of these diagnostic tools are discussed and the clinical scoring system (Renal Angina Index), which aims to provide a rational context for biomarker utilization, is also presented. Even if effective treatments are not currently available for established AKI, specific preventive approaches and some promising pharmacological treatments will be detailed. Renal replacement therapy is currently considered the most effective way to manage fluid balance when severe AKI occurs. Key Messages: Great efforts in pAKI research have today led to new strategies for early AKI detection and prevention strategies. Further studies have to be conducted in the next future in order to definitely improve the outcomes of pediatric patients experiencing this deadly syndrome.

U2 - 10.1159/000484968

DO - 10.1159/000484968

M3 - Article

C2 - 29393128

VL - 193

SP - 113

EP - 126

JO - Contributions to Nephrology

JF - Contributions to Nephrology

SN - 0302-5144

ER -