Pediatric adrenal diseases

Lucia Ghizzoni, Marco Cappa, George Chrousos, Sandro Loche, Mohamad Maghnie

Research output: Book/ReportBook

Abstract

Written by experts and specialized investigators, this book presents a detailed overview of the recent progress in our understanding of the adrenal cortex and its pivotal roles in homeostasis. Genes, molecules and cell compartments directly or indirectly involved in the complex steroidogenesis pathway as well as the resulting end-hormones glucocorticoids, mineralocorticoids and androgens are analyzed. Furthermore, the defects of the genes responsible both for common and rare adrenal disorders are presented. The interactions of the adrenal cortices with the adrenal medulla and their importance in the integration of adrenocortical and adrenomedullary function are discussed. The complex molecular pathophysiology of congenital adrenal hyperplasia is presented; long-term effects of the disorder and the still controversial antenatal therapy are examined. Finally, expert review chapters discuss autoimmune Addison disease and the adrenoleukodystrophy/adrenomyeloneuropathy syndrome. Presenting novel research findings in adrenal gland physiology and pathophysiology, this book is a useful tool not only for pediatric endocrinologists, but also for clinicians and researchers studying human development, organogenesis, mitochondrial biology, nuclear receptors, stress biology and pharmacology.

Original languageEnglish
PublisherS. Karger AG
Number of pages216
ISBN (Print)9783805596442, 9783805596435
DOIs
Publication statusPublished - Dec 17 2010

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Adrenoleukodystrophy
Pediatrics
Adrenal Cortex
Genes
Research Personnel
Addison Disease
Congenital Adrenal Hyperplasia
Mineralocorticoids
Adrenal Medulla
Organogenesis
Physiology
Human Development
Cytoplasmic and Nuclear Receptors
Adrenal Glands
Glucocorticoids
Androgens
Autoimmune Diseases
Homeostasis
Hormones
Pharmacology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Pediatric adrenal diseases. / Ghizzoni, Lucia; Cappa, Marco; Chrousos, George; Loche, Sandro; Maghnie, Mohamad.

S. Karger AG, 2010. 216 p.

Research output: Book/ReportBook

Ghizzoni L, Cappa M, Chrousos G, Loche S, Maghnie M. Pediatric adrenal diseases. S. Karger AG, 2010. 216 p. https://doi.org/10.1159/isbn.978-3-8055-9644-2
Ghizzoni, Lucia ; Cappa, Marco ; Chrousos, George ; Loche, Sandro ; Maghnie, Mohamad. / Pediatric adrenal diseases. S. Karger AG, 2010. 216 p.
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