Pediatric bronchiectasis: Correlation of HRCT, ventilation and perfusion scintigraphy, and pulmonary function testing

Massimo Pifferi, Davide Caramella, Alessandra Bulleri, Simonetta Baldi, Diego Peroni, Angelo Pietrobelli, Attilio L. Boner

Research output: Contribution to journalArticlepeer-review


Bronchiectasis in children, although occurring with diminished frequency, continues as a major challenge for the pediatric pulmonologist. The method of choice for the diagnosis of the condition is high-resolution computed tomography (HRCT). The aim of the present study was to correlate the relationship(s) of HRCT, lung function, ventilation lung scintigraphy (VLS), and perfusion lung scintigraphy (PLS) in children with bronchiectasis. Sixteen children ranging in age from 4-18 years with clinical and chest X-ray evidence of bronchiectasis were enrolled in the study. The degree of bronchiectasis was assessed by HRCT scores, decrease in attenuation on expiratory scans, VLS, and PLS. HRCT scores for bronchiectasis and decreased lung attenuation showed a strong correlation with PLS (p = 0.82; P <0.001) and with VLS (p = 0.72; P <0.01). There was a moderate negative correlation between FEV1 and HRCT bronchiectasis scores (p = -0.53; P= 0.02), decreased lung attenuation score (p = -0.64; P= 0.007), and atelectasis score (p = -0.54; P= 0.03). In conclusion, HRCT provides a complete and precise assessment of children with bronchiectasis. Ventilation/perfusion scans and lung functions are additive tools to understand the complexity of the disease process and to improve diagnosis and therapeutic strategies.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalPediatric Pulmonology
Issue number4
Publication statusPublished - Oct 2004


  • Bronchiectasis
  • Children
  • High-resolution computed tomography
  • Lung function
  • Ventilation/perfusion lung scintigraphy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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