Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein

Alberto Spalice, Francesca Del Balzo, Francesco Massimo Perla, Laura Papetti, Francesco Nicita, Fabiana Ursitti, Enrico Properzi

Research output: Contribution to journalArticle

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Abstract

Antibodies to 2-glycoprotein I (anti-2GPI) have been associated with recurrent thrombosis and pregnancy morbidity. However, the prevalence of anti-2GPI in children suffering from cerebral and cerebellar infarction is unknown. We report on a 10-month-old boy who had an ischemic cerebellar stroke, secondary to antiphospholipid syndrome with high titers of immunoglobulin G anti-2GPI (first titer: 132. U) anticardiolipin antibodies and lupus anticoagulant tests were negative. All other causes of infarction were excluded. To our knowledge, this is the first reported case of childhood cerebellar ischemic stroke with only anti-2GPI but no antibodies detectable in standard antiphospholipid assays.

Original languageEnglish
Pages (from-to)831-833
Number of pages3
JournalMedical Hypotheses
Volume76
Issue number6
DOIs
Publication statusPublished - Jun 2011

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Glycoproteins
Stroke
Pediatrics
Antibodies
Lupus Coagulation Inhibitor
Anticardiolipin Antibodies
Antiphospholipid Syndrome
Cerebral Infarction
Infarction
Thrombosis
Immunoglobulin G
Morbidity
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spalice, A., Del Balzo, F., Perla, F. M., Papetti, L., Nicita, F., Ursitti, F., & Properzi, E. (2011). Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein. Medical Hypotheses, 76(6), 831-833. https://doi.org/10.1016/j.mehy.2011.02.030

Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein. / Spalice, Alberto; Del Balzo, Francesca; Perla, Francesco Massimo; Papetti, Laura; Nicita, Francesco; Ursitti, Fabiana; Properzi, Enrico.

In: Medical Hypotheses, Vol. 76, No. 6, 06.2011, p. 831-833.

Research output: Contribution to journalArticle

Spalice, A, Del Balzo, F, Perla, FM, Papetti, L, Nicita, F, Ursitti, F & Properzi, E 2011, 'Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein', Medical Hypotheses, vol. 76, no. 6, pp. 831-833. https://doi.org/10.1016/j.mehy.2011.02.030
Spalice, Alberto ; Del Balzo, Francesca ; Perla, Francesco Massimo ; Papetti, Laura ; Nicita, Francesco ; Ursitti, Fabiana ; Properzi, Enrico. / Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein. In: Medical Hypotheses. 2011 ; Vol. 76, No. 6. pp. 831-833.
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