Abstract
Antibodies to 2-glycoprotein I (anti-2GPI) have been associated with recurrent thrombosis and pregnancy morbidity. However, the prevalence of anti-2GPI in children suffering from cerebral and cerebellar infarction is unknown. We report on a 10-month-old boy who had an ischemic cerebellar stroke, secondary to antiphospholipid syndrome with high titers of immunoglobulin G anti-2GPI (first titer: 132. U) anticardiolipin antibodies and lupus anticoagulant tests were negative. All other causes of infarction were excluded. To our knowledge, this is the first reported case of childhood cerebellar ischemic stroke with only anti-2GPI but no antibodies detectable in standard antiphospholipid assays.
| Original language | English |
|---|---|
| Pages (from-to) | 831-833 |
| Number of pages | 3 |
| Journal | Medical Hypotheses |
| Volume | 76 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |
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ASJC Scopus subject areas
- Medicine(all)
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Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein. / Spalice, Alberto; Del Balzo, Francesca; Perla, Francesco Massimo; Papetti, Laura; Nicita, Francesco; Ursitti, Fabiana; Properzi, Enrico.
In: Medical Hypotheses, Vol. 76, No. 6, 06.2011, p. 831-833.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein
AU - Spalice, Alberto
AU - Del Balzo, Francesca
AU - Perla, Francesco Massimo
AU - Papetti, Laura
AU - Nicita, Francesco
AU - Ursitti, Fabiana
AU - Properzi, Enrico
PY - 2011/6
Y1 - 2011/6
N2 - Antibodies to 2-glycoprotein I (anti-2GPI) have been associated with recurrent thrombosis and pregnancy morbidity. However, the prevalence of anti-2GPI in children suffering from cerebral and cerebellar infarction is unknown. We report on a 10-month-old boy who had an ischemic cerebellar stroke, secondary to antiphospholipid syndrome with high titers of immunoglobulin G anti-2GPI (first titer: 132. U) anticardiolipin antibodies and lupus anticoagulant tests were negative. All other causes of infarction were excluded. To our knowledge, this is the first reported case of childhood cerebellar ischemic stroke with only anti-2GPI but no antibodies detectable in standard antiphospholipid assays.
AB - Antibodies to 2-glycoprotein I (anti-2GPI) have been associated with recurrent thrombosis and pregnancy morbidity. However, the prevalence of anti-2GPI in children suffering from cerebral and cerebellar infarction is unknown. We report on a 10-month-old boy who had an ischemic cerebellar stroke, secondary to antiphospholipid syndrome with high titers of immunoglobulin G anti-2GPI (first titer: 132. U) anticardiolipin antibodies and lupus anticoagulant tests were negative. All other causes of infarction were excluded. To our knowledge, this is the first reported case of childhood cerebellar ischemic stroke with only anti-2GPI but no antibodies detectable in standard antiphospholipid assays.
UR - http://www.scopus.com/inward/record.url?scp=79955745062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955745062&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2011.02.030
DO - 10.1016/j.mehy.2011.02.030
M3 - Article
C2 - 21388749
AN - SCOPUS:79955745062
VL - 76
SP - 831
EP - 833
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 6
ER -