Pediatric craniospinal irradiation with conventional technique or helical tomotherapy: Impact of age and body volume on integral dose

Salvina Barra, Marco Gusinu, Giorgia Timon, Flavio Giannelli, Giulia Vidano, Maria Luisa Garre', Renzo Corvo

Research output: Contribution to journalArticle

Abstract

Purpose: The use of helical tomotherapy (HT) for craniospinal irradiation (CSI) in pediatric patients remains an issue of discussion. In this study, we evaluated the integral dose (ID) to organs at risk (OARs) and to the whole body delivered with conventional 3-dimensional conformal radiotherapy (3D-CRT) and HT for pediatric patients and made a comparison according to different whole body volumes. Methods: We selected 10 pediatric patients with different body volumes and of different ages undergoing CSI. Plans for 3D-CRT and HT were developed for each patient. The ID to OARs and to the whole body were compared and statistical analyses were performed to determine differences. Results: We noticed that variations of ID depend on the different anatomical location of the organs relatively to the target, with lower ID to OARs opposed to the target and increased ID to lateral organs: ID tomotherapy/3DCRT ratio was higher in lungs, kidneys, and mammary region, while it was lower in heart, liver, thyroid, and esophagus. The ID of the body increased with large volumes both in HT and in 3D-CRT plans, but in tomotherapy plans ID increased significantly more with large volumes than with small ones. Conclusions: While there are no differences in using tomotherapy or 3D-CRT with small body volumes, we found a difference with large volumes (≥20,000 mL vs ≤20,000 mL). Therefore, for very small patients, the use of intensity- modulated radiotherapy provided with tomotherapy to reduce the dose to OARs can be reconsidered.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalTumori
Volume102
Issue number4
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • Body volume
  • Craniospinal irradiation
  • Helical tomotherapy
  • Integral dose
  • Pediatric radiotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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