Pediatric drug hypersensitivity: Which diagnostic tests?

Francesca Saretta, Francesca Mori, Fabio Cardinale, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Carlo Caffarelli

Research output: Contribution to journalReview articlepeer-review


Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled. Only a few published studies evaluated sensitivity and specificity of skin and in vitro tests in children. However, selected case series show that diagnostic work-up for adults could be useful, with some limitations, in pediatric age. Indeed, despite improvement in in vivo and in vitro diagnosis, drug provocation test remains the gold standard in pediatric age, too. Unmet needs in children include multi-centric studies on incidence of DHR, utility and feasibility of in vivo and in vitro diagnostic tests and specifically dedicated guidelines for the diagnosis and management of DHR in children. (

Original languageEnglish
Pages (from-to)94-107
Number of pages14
JournalActa Biomedica
Publication statusPublished - Jan 1 2019


  • Basophil activation test
  • Children
  • Drug hypersensitivity reactions
  • Druprovocation test
  • Skin test
  • Specific IgE

ASJC Scopus subject areas

  • Medicine(all)


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