Abstract
Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled. Only a few published studies evaluated sensitivity and specificity of skin and in vitro tests in children. However, selected case series show that diagnostic work-up for adults could be useful, with some limitations, in pediatric age. Indeed, despite improvement in in vivo and in vitro diagnosis, drug provocation test remains the gold standard in pediatric age, too. Unmet needs in children include multi-centric studies on incidence of DHR, utility and feasibility of in vivo and in vitro diagnostic tests and specifically dedicated guidelines for the diagnosis and management of DHR in children. (www.actabiomedica.it).
| Original language | English |
|---|---|
| Pages (from-to) | 94-107 |
| Number of pages | 14 |
| Journal | Acta Biomedica |
| Volume | 90 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Basophil activation test
- Children
- Drug hypersensitivity reactions
- Druprovocation test
- Skin test
- Specific IgE
ASJC Scopus subject areas
- Medicine(all)
Cite this
Pediatric drug hypersensitivity : Which diagnostic tests? / Saretta, Francesca; Mori, Francesca; Cardinale, Fabio; Liotti, Lucia; Franceschini, Fabrizio; Crisafulli, Giuseppe; Caimmi, Silvia; Bottau, Paolo; Bernardini, Roberto; Caffarelli, Carlo.
In: Acta Biomedica, Vol. 90, 01.01.2019, p. 94-107.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pediatric drug hypersensitivity
T2 - Which diagnostic tests?
AU - Saretta, Francesca
AU - Mori, Francesca
AU - Cardinale, Fabio
AU - Liotti, Lucia
AU - Franceschini, Fabrizio
AU - Crisafulli, Giuseppe
AU - Caimmi, Silvia
AU - Bottau, Paolo
AU - Bernardini, Roberto
AU - Caffarelli, Carlo
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled. Only a few published studies evaluated sensitivity and specificity of skin and in vitro tests in children. However, selected case series show that diagnostic work-up for adults could be useful, with some limitations, in pediatric age. Indeed, despite improvement in in vivo and in vitro diagnosis, drug provocation test remains the gold standard in pediatric age, too. Unmet needs in children include multi-centric studies on incidence of DHR, utility and feasibility of in vivo and in vitro diagnostic tests and specifically dedicated guidelines for the diagnosis and management of DHR in children. (www.actabiomedica.it).
AB - Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled. Only a few published studies evaluated sensitivity and specificity of skin and in vitro tests in children. However, selected case series show that diagnostic work-up for adults could be useful, with some limitations, in pediatric age. Indeed, despite improvement in in vivo and in vitro diagnosis, drug provocation test remains the gold standard in pediatric age, too. Unmet needs in children include multi-centric studies on incidence of DHR, utility and feasibility of in vivo and in vitro diagnostic tests and specifically dedicated guidelines for the diagnosis and management of DHR in children. (www.actabiomedica.it).
KW - Basophil activation test
KW - Children
KW - Drug hypersensitivity reactions
KW - Druprovocation test
KW - Skin test
KW - Specific IgE
UR - http://www.scopus.com/inward/record.url?scp=85062392173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062392173&partnerID=8YFLogxK
U2 - 10.23750/abm.v90i3-S.8171
DO - 10.23750/abm.v90i3-S.8171
M3 - Review article
VL - 90
SP - 94
EP - 107
JO - Acta Biomedica de l'Ateneo Parmense
JF - Acta Biomedica de l'Ateneo Parmense
SN - 0392-4203
ER -