Pediatric HIV infection and bone health: An emerging challenge

Stefano Mora, Ilaria Zamproni, Gianvincenzo Zuccotti, Alessandra Vigano

Research output: Contribution to journalArticlepeer-review

Abstract

The available data indicate that HIV-infected children and adolescents have reduced bone mass compared to healthy peers. The increased survival due to the control of HIV infection by potent antiretroviral treatment, exposes patients to the achievement of a reduced peak bone mass and to an increased fracture risk during adult life. Reduced bone mass in HIV-infected children is the result of altered bone metabolism, showing significantly increased bone resorption rate. Both infection per se and the use of certain antiretroviral compounds seem to contribute to the altered metabolism. Preventative measures to improve bone health are thus necessary in all young patients that exhibit low bone mass measurements and altered bone metabolism.

Original languageEnglish
Pages (from-to)1265-1274
Number of pages10
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number4
Publication statusPublished - Jun 1 2010

Keywords

  • Antiretroviral treatment
  • Bone formation
  • Bone metabolism
  • Bone mineral density
  • Bone resorption
  • Children
  • Human immunodeficiency virus
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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