Pediatric inflammatory bowel disease: specificity of very early onset

Teresa Capriati, Sabrina Cardile, P. Papadatou, Claudio Romano, Daniela Knafelz, Fiammetta Bracci, Antonella Diamanti

Research output: Contribution to journalReview article

Abstract

Introduction: The incidence of inflammatory bowel disease (IBD) has increased over the last 50 years. It is now recognized that several genetic defects can express an IBD-like phenotype at very early onset (<6 years). Areas covered: The aim of this review was to update knowledge concerning the specificity of IBD at onset <6 years, which can include conventional/standard IBD as well as monogenic IBD-like diseases. Expert commentary: We found that females are less prone than males to develop monogenic disorders, which have X-linked heritability in several cases. Furthermore, the Crohn’s Diseases (CD) subtype seems to be suggestive of monogenic disorders while Unclassified IBD (IBDU) subtype is predominantly found in conventional/standard IBD at onset <6 years. Isolated colonic location is prevalent in both the subsets of IBD at onset <6 years if compared to IBD at later onset. Monogenic disorders require more aggressive medical and surgical treatments and can be complicated by the occurrence of lymphomas.

Original languageEnglish
Pages (from-to)963-972
Number of pages10
JournalExpert Review of Clinical Immunology
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • early onset
  • IBD-like
  • Inflammatory bowel disease
  • pediatric
  • pediatric-onset

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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