Pediatric inflammatory diseases. Part I: multiple sclerosis

A. Catalucci, M. Anselmi, A. Splendiani, J. D. Smith, N. Limbucci, F. Giangaspero, Massimo Gallucci

Research output: Contribution to journalArticlepeer-review


Multiple sclerosis (MS) is an inflammatory CNS disease characterized by multifocal areas of demyelination; usually it arises in young adults, but can also occur in children (under the age of 10) and adolescents (under the age of 18). As in adult, pediatric MS (PMS) diagnosis is based on the demonstration of multiple demyelination episodes separated in time and spaces. Diagnostic criteria realized for childhood are similar to those employed for adults. Although clinical and imaging features of PMS can be similar to those of adults, the disease is often characterized by a more aggressive course and atypical imaging findings, with giant and pseudotumoral plaques. Differential diagnosis between PMS and ADEM could be difficult: clinical findings and MRI are necessary; sometimes MRI follow-up is required for definitive diagnosis.

Original languageEnglish
Pages (from-to)684-694
Number of pages11
JournalNeuroradiology Journal
Issue number6
Publication statusPublished - Dec 2012


  • Giant plaques
  • MRI
  • Pediatric multiple sclerosis (PMS)

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging


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