Pediatric liver transplantation using left hepatic segments from living related donors: Surgical experience in 100 recipients at Saint-Luc University Clinics

Ahmed A. Darwish, Christophe Bourdeaux, Hesham A. Kader, Magda Janssen, Etienne Sokal, Jan Lerut, Olga Ciccarelli, Francis Veyckemans, Jean Bernard Otte, Jean De Ville De Goyet, Raymond Reding

Research output: Contribution to journalArticle

Abstract

Living-related liver transplantation was developed in the context of deceased donor organ shortage, which is particularly acute for pediatric recipients. This retrospective study analyzes the surgical technique and complications in the first 100 pediatric liver transplantation using left segmental liver grafts from living donors, performed at Saint-Luc University Clinics between July 1993 and April 2002. Pre-operative evaluation in donors and recipients, analysis of the surgical technique, and postoperative complications were reviewed. After a median follow-up period of 2526 days, no donor mortality was encountered, with a minimal morbidity and no long-term sequelae. At one and five yr post-transplantation, the actuarial patient survival rates were 94% and 92%, the corresponding figures being 92% and 89% for graft survival. The incidences of portal vein and hepatic artery thromboses, and of biliary complications were 14%, 1%, and 27%, respectively. Living-related liver transplantation in children constitutes an efficient therapy for liver failure to face the increased demand for liver grafts. Donor morbidity was kept to acceptable incidence, and surgical technique in the recipient needs to be tailored to minimize postoperative complications.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalPediatric Transplantation
Volume10
Issue number3
DOIs
Publication statusPublished - May 2006

Fingerprint

Saints
Living Donors
Liver Transplantation
Tissue Donors
Pediatrics
Liver
Morbidity
Transplants
Hepatic Artery
Incidence
Liver Failure
Graft Survival
Portal Vein
Thrombosis
Survival Rate
Retrospective Studies
Transplantation
Mortality
Therapeutics

Keywords

  • Complications
  • Living donation
  • Pediatric liver transplantation
  • Surgical technique

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Pediatric liver transplantation using left hepatic segments from living related donors : Surgical experience in 100 recipients at Saint-Luc University Clinics. / Darwish, Ahmed A.; Bourdeaux, Christophe; Kader, Hesham A.; Janssen, Magda; Sokal, Etienne; Lerut, Jan; Ciccarelli, Olga; Veyckemans, Francis; Otte, Jean Bernard; Goyet, Jean De Ville De; Reding, Raymond.

In: Pediatric Transplantation, Vol. 10, No. 3, 05.2006, p. 345-353.

Research output: Contribution to journalArticle

Darwish, AA, Bourdeaux, C, Kader, HA, Janssen, M, Sokal, E, Lerut, J, Ciccarelli, O, Veyckemans, F, Otte, JB, Goyet, JDVD & Reding, R 2006, 'Pediatric liver transplantation using left hepatic segments from living related donors: Surgical experience in 100 recipients at Saint-Luc University Clinics', Pediatric Transplantation, vol. 10, no. 3, pp. 345-353. https://doi.org/10.1111/j.1399-3046.2005.00477.x
Darwish, Ahmed A. ; Bourdeaux, Christophe ; Kader, Hesham A. ; Janssen, Magda ; Sokal, Etienne ; Lerut, Jan ; Ciccarelli, Olga ; Veyckemans, Francis ; Otte, Jean Bernard ; Goyet, Jean De Ville De ; Reding, Raymond. / Pediatric liver transplantation using left hepatic segments from living related donors : Surgical experience in 100 recipients at Saint-Luc University Clinics. In: Pediatric Transplantation. 2006 ; Vol. 10, No. 3. pp. 345-353.
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