Pediatric motor inflammatory neuropathy: The role of antiphospholipid antibodies

Claudia Brogna; Marco Luigetti; Giulia Norcia; Roberta Scalise; Gloria Ferrantini; Beatrice Berti; Domenico M. Romeo; Raffaele Manna; Eugenio Mercuri; Marika Pane

doi:10.3390/brainsci10030156

Pediatric motor inflammatory neuropathy: The role of antiphospholipid antibodies

Claudia Brogna, Marco Luigetti, Giulia Norcia, Roberta Scalise, Gloria Ferrantini, Beatrice Berti, Domenico M. Romeo, Raffaele Manna, Eugenio Mercuri, Marika Pane

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.

Original language	English
Article number	156
Journal	Brain Sciences
Volume	10
Issue number	3
DOIs	https://doi.org/10.3390/brainsci10030156
Publication status	Published - Mar 2020

Keywords

Antiphospholipid antibodies
IVIG
Pediatric motor neuropathy

ASJC Scopus subject areas

Neuroscience(all)

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10.3390/brainsci10030156

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Pediatric motor inflammatory neuropathy : The role of antiphospholipid antibodies. / Brogna, Claudia; Luigetti, Marco; Norcia, Giulia; Scalise, Roberta; Ferrantini, Gloria; Berti, Beatrice; Romeo, Domenico M.; Manna, Raffaele ; Mercuri, Eugenio ; Pane, Marika.

In: Brain Sciences, Vol. 10, No. 3, 156, 03.2020.

Research output: Contribution to journal › Article › peer-review

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