TY - JOUR
T1 - Pediatric motor inflammatory neuropathy
T2 - The role of antiphospholipid antibodies
AU - Brogna, Claudia
AU - Luigetti, Marco
AU - Norcia, Giulia
AU - Scalise, Roberta
AU - Ferrantini, Gloria
AU - Berti, Beatrice
AU - Romeo, Domenico M.
AU - Manna, Raffaele
AU - Mercuri, Eugenio
AU - Pane, Marika
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.
AB - We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.
KW - Antiphospholipid antibodies
KW - IVIG
KW - Pediatric motor neuropathy
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U2 - 10.3390/brainsci10030156
DO - 10.3390/brainsci10030156
M3 - Article
AN - SCOPUS:85081221436
VL - 10
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 3
M1 - 156
ER -