Pediatric motor inflammatory neuropathy: The role of antiphospholipid antibodies

Claudia Brogna, Marco Luigetti, Giulia Norcia, Roberta Scalise, Gloria Ferrantini, Beatrice Berti, Domenico M. Romeo, Raffaele Manna, Eugenio Mercuri, Marika Pane

Research output: Contribution to journalArticlepeer-review


We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.

Original languageEnglish
Article number156
JournalBrain Sciences
Issue number3
Publication statusPublished - Mar 2020


  • Antiphospholipid antibodies
  • IVIG
  • Pediatric motor neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)


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