Pediatric non alcoholic fatty liver disease: Old and new concepts on development, progression, metabolic insight and potential treatment targets

Valentina Giorgio, Federica Prono, Francesca Graziano, Valerio Nobili

Research output: Contribution to journalArticle

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender. It is defined by hepatic fat infiltration >5% hepatocytes, in the absence of other causes of liver pathology. It includes a spectrum of disease ranging from intrahepatic fat accumulation (steatosis) to various degrees of necrotic inflammation and fibrosis (non-alcoholic steatohepatatis [NASH]). NAFLD is associated, in children as in adults, with severe metabolic impairments, determining an increased risk of developing the metabolic syndrome. It can evolve to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Both genetic and environmental factors seem to be involved in the development and progression of the disease, but its physiopathology is not yet entirely clear. In view of this mounting epidemic phenomenon involving the youth, the study of NAFLD should be a priority for all health care systems. This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives.

Original languageEnglish
Article number40
JournalBMC Pediatrics
Volume13
Issue number1
DOIs
Publication statusPublished - Mar 25 2013

Fingerprint

Pediatrics
Fibrosis
Fats
Therapeutics
Liver
Liver Transplantation
Disease Progression
Liver Diseases
Hepatocytes
Hepatocellular Carcinoma
Chronic Disease
Obesity
Non-alcoholic Fatty Liver Disease
Pathology
Inflammation
Delivery of Health Care

Keywords

  • Metabolic syndrome
  • Non-alcoholic steatohepatatis
  • Nonalcoholic fatty liver disease
  • Obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pediatric non alcoholic fatty liver disease : Old and new concepts on development, progression, metabolic insight and potential treatment targets. / Giorgio, Valentina; Prono, Federica; Graziano, Francesca; Nobili, Valerio.

In: BMC Pediatrics, Vol. 13, No. 1, 40, 25.03.2013.

Research output: Contribution to journalArticle

@article{9dcfdfb1726a45cda43b95ddb5536698,
title = "Pediatric non alcoholic fatty liver disease: Old and new concepts on development, progression, metabolic insight and potential treatment targets",
abstract = "Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender. It is defined by hepatic fat infiltration >5{\%} hepatocytes, in the absence of other causes of liver pathology. It includes a spectrum of disease ranging from intrahepatic fat accumulation (steatosis) to various degrees of necrotic inflammation and fibrosis (non-alcoholic steatohepatatis [NASH]). NAFLD is associated, in children as in adults, with severe metabolic impairments, determining an increased risk of developing the metabolic syndrome. It can evolve to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Both genetic and environmental factors seem to be involved in the development and progression of the disease, but its physiopathology is not yet entirely clear. In view of this mounting epidemic phenomenon involving the youth, the study of NAFLD should be a priority for all health care systems. This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives.",
keywords = "Metabolic syndrome, Non-alcoholic steatohepatatis, Nonalcoholic fatty liver disease, Obesity",
author = "Valentina Giorgio and Federica Prono and Francesca Graziano and Valerio Nobili",
year = "2013",
month = "3",
day = "25",
doi = "10.1186/1471-2431-13-40",
language = "English",
volume = "13",
journal = "BMC Pediatrics",
issn = "1471-2431",
publisher = "BMC",
number = "1",

}

TY - JOUR

T1 - Pediatric non alcoholic fatty liver disease

T2 - Old and new concepts on development, progression, metabolic insight and potential treatment targets

AU - Giorgio, Valentina

AU - Prono, Federica

AU - Graziano, Francesca

AU - Nobili, Valerio

PY - 2013/3/25

Y1 - 2013/3/25

N2 - Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender. It is defined by hepatic fat infiltration >5% hepatocytes, in the absence of other causes of liver pathology. It includes a spectrum of disease ranging from intrahepatic fat accumulation (steatosis) to various degrees of necrotic inflammation and fibrosis (non-alcoholic steatohepatatis [NASH]). NAFLD is associated, in children as in adults, with severe metabolic impairments, determining an increased risk of developing the metabolic syndrome. It can evolve to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Both genetic and environmental factors seem to be involved in the development and progression of the disease, but its physiopathology is not yet entirely clear. In view of this mounting epidemic phenomenon involving the youth, the study of NAFLD should be a priority for all health care systems. This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives.

AB - Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender. It is defined by hepatic fat infiltration >5% hepatocytes, in the absence of other causes of liver pathology. It includes a spectrum of disease ranging from intrahepatic fat accumulation (steatosis) to various degrees of necrotic inflammation and fibrosis (non-alcoholic steatohepatatis [NASH]). NAFLD is associated, in children as in adults, with severe metabolic impairments, determining an increased risk of developing the metabolic syndrome. It can evolve to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Both genetic and environmental factors seem to be involved in the development and progression of the disease, but its physiopathology is not yet entirely clear. In view of this mounting epidemic phenomenon involving the youth, the study of NAFLD should be a priority for all health care systems. This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives.

KW - Metabolic syndrome

KW - Non-alcoholic steatohepatatis

KW - Nonalcoholic fatty liver disease

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84875320909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875320909&partnerID=8YFLogxK

U2 - 10.1186/1471-2431-13-40

DO - 10.1186/1471-2431-13-40

M3 - Article

C2 - 23530957

AN - SCOPUS:84875320909

VL - 13

JO - BMC Pediatrics

JF - BMC Pediatrics

SN - 1471-2431

IS - 1

M1 - 40

ER -